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Editorial| Volume 184, 109710, March 2023

Can early blood biomarkers guide brain imaging strategy after cardiac arrest?

      Neuroprognostication is an essential step in care of patients who remain comatose within the first days after cardiac arrest.
      • Perkins G.D.
      • Callaway C.W.
      • Haywood K.
      • et al.
      Brain injury after cardiac arrest.
      Many do not recover consciousness or suffer from severe, persisting disorders of consciousness
      • Edlow B.L.
      • Claassen J.
      • Schiff N.D.
      • Greer D.M.
      Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies.
      and thus, information on the severity of a possible hypoxic-ischemic encephalopathy (HIE) is important to align goals of care with the patients’ will and to provide realistic expectations to relatives. Clinical research over the past decades has established an array of diagnostic tools for this purpose. As each of those may falsely predict poor outcome in individual patients, current guidelines recommend a multimodal strategy for prognostication, including clinical examination, electrophysiology, blood biomarkers and brain imaging.
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