Neuroprognostication is an essential step in care of patients who remain comatose
within the first days after cardiac arrest.
1
Many do not recover consciousness or suffer from severe, persisting disorders of
consciousness
2
and thus, information on the severity of a possible hypoxic-ischemic encephalopathy
(HIE) is important to align goals of care with the patients’ will and to provide realistic
expectations to relatives. Clinical research over the past decades has established
an array of diagnostic tools for this purpose. As each of those may falsely predict
poor outcome in individual patients, current guidelines recommend a multimodal strategy
for prognostication, including clinical examination, electrophysiology, blood biomarkers
and brain imaging.To read this article in full you will need to make a payment
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References
- Brain injury after cardiac arrest.Lancet. 2021; 398: 1269-1278
- Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies.Nat Rev Neurol. 2021; 17: 135-156
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive Care Med. 2021; 47: 369-421
- Serum neuron-specific enolase levels from the same patients differ between laboratories: assessment of a prospective post-cardiac arrest cohort.Neurocrit Care. 2013; 19: 161-166
- Serum tau and neurological outcome in cardiac arrest.Ann Neurol. 2017; 82: 665-675
- Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.JAMA Neurol. 2019; 76: 64-71
- GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest: A post hoc analysis of the COMACARE trial.Resuscitation. 2022; 170: 141-149
- Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients.Resuscitation. 2020; 154: 61-68
- Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial.Intensive Care Med. 2021; 47: 39-48
- Neurofilament light compared to neuron-specific enolase as a predictor of unfavourable outcome after out-of-hospital cardiac arrest.Resuscitation. 2022; 174: 1-8
- Neuroimaging in Cardiac Arrest Prognostication.Semin Neurol. 2017; 37: 66-74
- Automated Assessment of Brain CT After Cardiac Arrest-An Observational Derivation/Validation Cohort Study.Crit Care Med. 2021; 49: e1212-e1222
- Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review.Intensive Care Med. 2022; 48: 389-413
- Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest.N Engl J Med. 2013; 369: 2197-2206
- Brain injury markers in blood predict signs of hypoxic ischaemic encephalopathy on head computed tomography after cardiac arrest.Resuscitation. 2022;
Article info
Publication history
Published online: January 27, 2023
Accepted:
January 21,
2023
Received:
January 19,
2023
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
