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Review| Volume 184, 109708, March 2023

On-site treatment of avalanche victims: Scoping review and 2023 recommendations of the international commission for mountain emergency medicine (ICAR MedCom)

  • M. Pasquier
    Correspondence
    Corresponding author at: Department of Emergency Medicine, Lausanne University Hospital and University of Lausanne, BH09, 1011 Lausanne, Switzerland. Fax: + 41 21 314 55 90.
    Affiliations
    Emergency Department, Lausanne University Hospital, Lausanne, Switzerland

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • G. Strapazzon
    Affiliations
    Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy

    Medical University Innsbruck, Innsbruck, Austria

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zurich, Switzerland
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  • A. Kottmann
    Affiliations
    Swiss Air Ambulance – Rega, Zurich Airport, Switzerland

    Emergency Department, Lausanne University Hospital, Lausanne, Switzerland

    Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • P. Paal
    Affiliations
    Department of Anaesthesiology and Intensive Care Medicine, St. John of God Hospital, Paracelsus Medical University Salzburg, Austria

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zurich, Switzerland
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  • K. Zafren
    Affiliations
    Department of Emergency Medicine, Alaska Native Medical Center Anchorage, Alaska, USA

    Department of Emergency Medicine Stanford University Medical Center Stanford, CA, USA

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • K. Oshiro
    Affiliations
    Cardiovascular Department, Mountain Medicine, Research, & Survey Division, Hokkaido Ohno Memorial Hospital, Hokkaido, Japan

    Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • C. Artoni
    Affiliations
    ICAR Avalanche Rescue Commission, Zürich, Switzerland
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  • C. Van Tilburg
    Affiliations
    Providence Hood River Memorial Hospital, Hood River, Oregon, USA

    Mountain Rescue Association, USA

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • A. Sheets
    Affiliations
    Emergency Department, Boulder Community Health, Boulder, CO, USA

    University of Colorado Wilderness and Environmental Medicine Fellowship Faculty, Aurora, CO, USA

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • J. Ellerton
    Affiliations
    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • K. McLaughlin
    Affiliations
    Canmore Hospital, Alberta, Canada

    University of Calgary, Canada

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • L. Gordon
    Affiliations
    Department of Anaesthesia, University Hospitals of Morecambe Bay Trust, Lancaster, England

    Langdale Ambleside Mountain Rescue Team, England

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • R.W. Martin
    Affiliations
    Mountain Rescue Association, USA

    ICAR Avalanche Rescue Commission, Zürich, Switzerland
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  • M. Jacob
    Affiliations
    Bavarian Mountain Rescue Service, Bad Tölz, Germany

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • M. Musi
    Affiliations
    Emergency Department, University of Colorado, Aurora, Colorado, USA

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • M. Blancher
    Affiliations
    Department of Emergency Medicine, University Hospital of Grenoble Alps Grenoble, France

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland
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  • C. Jaques
    Affiliations
    Lausanne University Medical Library, Lausanne, Switzerland
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  • H. Brugger
    Affiliations
    Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy

    Medical University Innsbruck, Innsbruck, Austria

    International Commission for Mountain Emergency Medicine (ICAR MedCom), Zurich, Switzerland
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Open AccessPublished:January 25, 2023DOI:https://doi.org/10.1016/j.resuscitation.2023.109708

      Abstract

      Introduction

      The International Commission for Mountain Emergency Medicine (ICAR MedCom) developed updated recommendations for the management of avalanche victims.

      Methods

      ICAR MedCom created Population Intervention Comparator Outcome (PICO) questions and conducted a scoping review of the literature. We evaluated and graded the evidence using the American College of Chest Physicians system.

      Results

      We included 120 studies including original data in the qualitative synthesis. There were 45 retrospective studies (38%), 44 case reports or case series (37%), and 18 prospective studies on volunteers (15%). The main cause of death from avalanche burial was asphyxia (range of all studies 65–100%). Trauma was the second most common cause of death (5–29%). Hypothermia accounted for few deaths (0–4%).

      Conclusions and recommendations

      For a victim with a burial time ≤ 60 minutes without signs of life, presume asphyxia and provide rescue breaths as soon as possible, regardless of airway patency. For a victim with a burial time > 60 minutes, no signs of life but a patent airway or airway with unknown patency, presume that a primary hypothermic CA has occurred and initiate cardiopulmonary resuscitation (CPR) unless temperature can be measured to rule out hypothermic cardiac arrest. For a victim buried > 60 minutes without signs of life and with an obstructed airway, if core temperature cannot be measured, rescuers can presume asphyxia-induced CA, and should not initiate CPR. If core temperature can be measured, for a victim without signs of life, with a patent airway, and with a core temperature < 30 °C attempt resuscitation, regardless of burial duration.

      Keywords

      Introduction

      In 1996 the International Commission for Mountain Emergency Medicine (ICAR MedCom) established field management guidelines including an algorithm for the prehospital management of persons buried in avalanches.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      On-site triage of avalanche victims with asystole by the emergency doctor.
      The guidelines were updated in 2002
      • Brugger H.
      • Durrer B.
      On-site treatment of avalanche victims ICAR-MEDCOM-recommendation.
      and 2013.
      • Brugger H.
      • Durrer B.
      • Elsensohn F.
      • et al.
      Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel.
      Since 2010, avalanche burial has been classified as a special type of cardiac arrest (CA) in the recommendations of the European Resuscitation Council (ERC).
      • Soar J.
      • Perkins G.D.
      • Abbas G.
      • et al.
      European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution.
      • Vanden Hoek T.L.
      • Morrison L.J.
      • Shuster M.
      • et al.
      Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.
      In 2015
      • Truhlar A.
      • Deakin C.D.
      • Soar J.
      • et al.
      European Resuscitation Council Guidelines for Resuscitation 2015: Section 4.
      the ERC published a resuscitation algorithm for victims buried in avalanches. The ERC updated the algorithm in the 2021 ERC guidelines.
      • Lott C.
      • Truhlář A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      In 2017 the Wilderness Medical Society (WMS) published recommendations for the prevention and management of avalanche and non-avalanche snow burial accidents.
      • Van Tilburg C.
      • Grissom C.K.
      • Zafren K.
      • et al.
      Wilderness Medical Society Practice Guidelines for Prevention and Management of Avalanche and Nonavalanche Snow Burial Accidents.
      The overall level of evidence used in constructing the recommendations was low.
      • Brugger H.
      • Durrer B.
      • Elsensohn F.
      • et al.
      Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel.
      Our goal was to develop evidence-based updated recommendations for the prehospital management of avalanche victims.

      Methods

      We conducted a scoping review of avalanche-specific knowledge by systematically assessing and synthesising the available evidence. We collected the reported outcomes of avalanche victims using all reported definitions regarding avalanche-specific terminology, including airway patency, air pocket, and degree of burial. In parallel, we constructed a list of Population, Intervention, Comparator and Outcomes (PICO) questions to focus on the most important questions pertaining to the management of avalanche victims. From the results of the scoping review, we produced a narrative summary of the rationale and evidence. We developed management recommendations by consensus. The final manuscript was endorsed by ICAR MedCom at the ICAR assembly in Montreux, Switzerland on 15 October 2022.

      Scoping review

      The protocol for the scoping review was registered on 14 October 2021 and is available at the URL: https://osf.io/x7u2n/. We considered studies including victims of any age involved in avalanche accidents and experimental studies on manikins, animals, and healthy volunteers. We only included review articles if they focused on avalanche burial and rescue. We excluded letters and other correspondence unless they included new data or scientific content. We excluded studies of related topics not specific to avalanche victims that did not include any data from avalanche victims and studies of avalanche prevention and location of victims.
      We performed the literature search for studies of avalanche-specific knowledge, designed with the help of a research librarian (CJ), on 18 October 2021 and updated it on 25 August 2022. Databases we accessed were PubMed, Embase.com, Cochrane Central Register of Controlled Trials Wiley and Web of Science Core collection. Clinical trials registries accessed were: Clinicaltrials.gov and the WHO International Clinical Trials Registry Platform. The completed strategies were peer reviewed by another information specialist using the PRESS Checklist (Supplemental file 1).
      • McGowan J.
      • Sampson M.
      • Salzwedel D.M.
      • et al.
      PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement.
      There were no restrictions on language or date of the studies.
      We reviewed the records identified by the search to eliminate duplicates and then uploaded them into EndNote™ 20 (Clarivate™). Two reviewers (GS and MP) independently screened the titles and abstracts of the retrieved studies to check for eligibility, using the Rayyan app for systematic reviews.
      • Ouzzani M.
      • Hammady H.
      • Fedorowicz Z.
      • Elmagarmid A.
      Rayyan-a web and mobile app for systematic reviews.
      We retrieved all eligible references in full text. They were independently analysed by each reviewer to confirm that they met the inclusion criteria. We resolved disagreements by consensus between the reviewers.
      We extracted the following data: year of publication, nationality of the first author, language, and type of study. We identified mass casualty incidents, defined arbitrarily as events with at least 10 victims. We classified retrospective studies with fewer than five victims as case reports or case series. We reported the scoping review following the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) statement (Supplemental file 2).
      • Tricco A.C.
      • Lillie E.
      • Zarin W.
      • et al.
      PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation.

      Terminology

      We used the following terminology to describe the medical aspects of the management of avalanche victims:
      Air pocket: An air pocket is any space in front of the mouth and nose in a victim with a patent airway.
      • Kottmann A.
      • Pasquier M.
      • Strapazzon G.
      • et al.
      Quality Indicators for Avalanche Victim Management and Rescue.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      The term ‘no air pocket’ is only documented if the extricated victim’s mouth and nose are found to be completely filled with snow or debris.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      On-site triage of avalanche victims with asystole by the emergency doctor.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      Airway patency: The terms obstructed airway and blocked airway require that both the mouth and nose be completely filled with compacted snow or debris. The obstruction can be caused by snow or vomitus. If there is no information about airway patency, the airway should be presumed to be patent and the victim treated accordingly. ‘Unknown patency’ should be documented in the patient record.
      Critical burial: The term critical burial refers to a burial in which the head and chest are buried under snow.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      • Brugger H.
      • Durrer B.
      • Elsensohn F.
      • et al.
      Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel.
      • Lott C.
      • Truhlar A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      ECLS rewarming: Extracorporeal life support (ECLS) rewarming includes rewarming with cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO).
      Signs of life: Signs of life include any of the following: A, V or P from AVPU (alert, responsive to verbal stimuli, responsive to pain, unresponsive) or Glasgow Coma Scale > 3, any visible movement, respirations, or a palpable carotid or femoral pulse.
      • Musi M.E.
      • Sheets A.
      • Zafren K.
      • et al.
      Clinical staging of accidental hypothermia: The Revised Swiss System: Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom).
      Ultrasound may expand the options to detect signs of life, using echocardiography or doppler ultrasound of large arteries.

      PICO questions

      We used a list of questions to focus on the most important decision points involved in the management of avalanche victims. We used the PICO format when appropriate. The writing group developed the original list of questions. We then opened the list for comments in the closed forum of ICAR MedCom for 15 days. The writing group voted on the 25 questions. We excluded two questions, leaving 23 questions on the final list (Supplemental file 3).

      Recommendations and algorithm

      For avalanche-specific recommendations, we used the results of the literature search and the answers to the PICO questions. For recommendations that were not avalanche-specific, we used the most recent recommendations for general medical management.
      • Lott C.
      • Truhlář A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      • Dow J.
      • Giesbrecht G.G.
      • Danzl D.F.
      • et al.
      Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update.
      • Sumann G.
      • Moens D.
      • Brink B.
      • et al.
      Multiple trauma management in mountain environments - a scoping review : Evidence based guidelines of the International Commission for Mountain Emergency Medicine (ICAR MedCom). Intended for physicians and other advanced life support personnel. Scand J Trauma Resusc.
      • Schon C.A.
      • Gordon L.
      • Holzl N.
      • et al.
      Determination of Death in Mountain Rescue: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom).
      • Musi M.E.
      • Sheets A.
      • Zafren K.
      • et al.
      Clinical staging of accidental hypothermia: The Revised Swiss System: Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom).
      • Paal P.
      • Gordon L.
      • Strapazzon G.
      • et al.
      Accidental hypothermia-an update : The content of this review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).
      We discussed the recommendations within the ICAR MedCom to reach a consensus. We graded the evidence using the American College of Chest Physicians grading system (Table 1).
      • Guyatt G.
      • Gutterman D.
      • Baumann M.H.
      • et al.
      Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force.
      Finally, we constructed an algorithm for avalanche rescue. We updated the avalanche victim resuscitation checklist
      • Kottmann A.
      • Blancher M.
      • Pasquier M.
      • Brugger H.
      Avalanche Victim Resuscitation Checklist adaption to the 2015 ERC Resuscitation guidelines.
      based on the updated algorithm.
      Table 1Grading strength of recommendations and quality of evidence in clinical guidelines (American College of Chest Physicians).
      • Guyatt G.
      • Gutterman D.
      • Baumann M.H.
      • et al.
      Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force.
      Grade of Recommendation/ DescriptionBenefit vs Risk and BurdensMethodological Quality of Supporting EvidenceImplications
      1A/strong recommendation, high-quality evidenceBenefits clearly outweigh risk and burdens, or vice versaRCTs without important limitations or overwhelming evidence from observational studiesStrong recommendation, can apply to most patients in most circumstances without reservation
      1B/strong recommendation, moderate quality evidenceBenefits clearly outweigh risk and burdens, or vice versaRCTs with important limitations (inconsistent results, methodological flaws, indirect, or imprecise) or exceptionally strong evidence from observational studiesStrong recommendation, can apply to most patients in most circumstances without reservation
      1C/strong recommendation, low-quality or very low-quality evidenceBenefits clearly outweigh risk and burdens, or vice versaObservational studies or case seriesStrong recommendation but may change when higher quality evidence becomes available
      2A/weak recommendation, high-quality evidenceBenefits closely balanced with risks and burdenRCTs without important limitations or overwhelming evidence from observational studiesWeak recommendation, best action may differ depending on circumstances or patients’ or societal values
      2B/weak recommendation, moderate-quality evidenceBenefits closely balanced with risks and burdenRCTs with important limitations (inconsistent results, methodological flaws, indirect, or imprecise) or exceptionally strong evidence from observational studiesWeak recommendation, best action may differ depending on circumstances or patients’ or societal values
      2C/weak recommendation, low-quality or very low-quality evidenceUncertainty in the estimates of benefits, risks, and burden; benefits, risk, and burden may be closely balancedObservational studies or case seriesVery weak recommendations; other alternatives may be equally reasonable

      Results

      We identified 157 studies for possible inclusion. Thirty-five of the studies were reviews or guidelines and two were research protocols. The remaining 120 studies presented original data and were included in the qualitative synthesis (Fig. 1).
      Figure thumbnail gr1
      Fig. 1Flow diagram of the search. We included two studies with original retrospective data, management recommendations, and the ICAR algorithm
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      • Brugger H.
      • Falk M.
      Adler-Kastner L.
      in the qualitative synthesis group.
      The study types were 45 retrospective studies (38 %), 44 case reports or case series (37 %), 18 prospective studies, including seven randomised-controlled studies with volunteers
      • Strapazzon G.
      • Malacrida S.
      • Governo E.
      • et al.
      An artificial air pocket device reduces inspired level of carbon dioxide in participants completely buried in avalanche debris: an experimental, randomized crossover study.
      • Brugger H.
      • Sumann G.
      • Meister R.
      • et al.
      Hypoxia and hypercapnia during respiration into an artificial air pocket in snow: implications for avalanche survival.
      • McIntosh S.E.
      • Crouch A.K.
      • Dorais A.
      • et al.
      Effect of head and face insulation on cooling rate during snow burial.
      • Roubík K.
      • Sieger L.
      • Sykora K.
      Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study.
      • Wallner B.
      • Moroder L.
      • Brandt A.
      • et al.
      Extrication Times During Avalanche Companion Rescue: A Randomized Single-Blinded Manikin Study.
      • Wik L.
      • Brattebo G.
      • Osteras O.
      • et al.
      Physiological effects of providing supplemental air for avalanche victims.
      • Wallner B.
      • Moroder L.
      • Salchner H.
      • et al.
      CPR with restricted patient access using alternative rescuer positions: a randomised cross-over manikin study simulating the CPR scenario after avalanche burial.
      (15 %), eight descriptions of mass casualty incidents (7 %), three observational studies (surveys) of avalanche victims (2 %) and two prospective studies on animals (2 %).
      Three countries accounted for more than a half of the 120 reports: Austria (19 %), Italy (18 %) and Switzerland (17 %) (Supplemental file 4). There was an increase in the annual number of reports over the years.

      Summary of the evidence

      Survival

      Human retrospective data

      The degree of burial is closely related to survival. Of 1886 avalanche victims in one large study, 96 % of the victims not buried or partially buried were alive at extrication, compared with 48 % of those critically buried (p < 0.001).
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      In five studies, the percentage of victims surviving critical burial ranged from 39 % to 48 %.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      • Armstrong B.R.
      AVALANCHE ACCIDENT VICTIMS IN THE USA.
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      • Hohlrieder M.
      • Mair P.
      • Wuertl W.
      • Brugger H.
      The impact of avalanche transceivers on mortality from avalanche accidents.
      In a single study, survival was lower in victims extricated by organised rescue (19 %) compared with companion rescue (74 %).
      • Mair P.
      • Frimmel C.
      • Vergeiner G.
      • et al.
      Emergency medical helicopter operations for avalanche accidents.
      Overall survival was 18 % in a study of 109 victims.
      • Hohlrieder M.
      • Thaler S.
      • Wuertl W.
      • et al.
      Rescue missions for totally buried avalanche victims: conclusions from 12 years of experience.
      In a study, from a helicopter emergency medical system (HEMS), of 66 avalanche victims in CA, no victim survived. Seven (11 %) became organ donors. Thirty-one (47 %) were declared dead at the scene, seven (11 %) had a prehospital return of spontaneous circulation (ROSC), and 25 (38 %) had persistent CA in hospital, of whom seven underwent extracorporeal life support (ECLS) rewarming.
      • Métrailler-Mermoud J.
      • Hugli O.
      • Carron P.N.
      • et al.
      Avalanche victims in cardiac arrest are unlikely to survive despite adherence to medical guidelines.
      In another study of 170 avalanche victims in CA rescued by HEMS, only one victim survived after a long burial. The victim was hypothermic and underwent ECLS rewarming. The victim survived neurologically intact with cerebral performance category (CPC) 1.
      • Strapazzon G.
      • Plankensteiner J.
      • Mair P.
      • et al.
      Prehospital management and outcome of avalanche patients with out-of-hospital cardiac arrest: a retrospective study in Tyrol.
      • Oberhammer R.
      • Beikircher W.
      • Hörmann C.
      • et al.
      Full recovery of an avalanche victim with profound hypothermia and prolonged cardiac arrest treated by extracorporeal re-warming.
      In another study of 55 avalanche victims who experienced out-of-hospital CA (OHCA), five (9 %) survived to hospital discharge, only two had good neurological outcomes.
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      Other studies involved avalanche victims with OHCA who were admitted to hospital. In one study of 37 victims, 18 (49 %) had prehospital ROSC, 19 (51 %) underwent ECLS rewarming, and 12 (32 %) survived to hospital discharge. Three (9 %) had good neurological outcomes.
      • Ruttmann E.
      • Dietl M.
      • Kastenberger T.
      • et al.
      Characteristics and outcome of patients with hypothermic out-of-hospital cardiac arrest: Experience from a European trauma center.
      In another study of 48 victims, eight (17 %) survived.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      In a multi-center study of 61 avalanche victims admitted to ECLS centres in CA, six (10 %) survived.
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      In a study of 28 avalanche victims rewarmed with ECLS, two (7 %) survived.
      • Mair P.
      • Brugger H.
      • Mair B.
      • Moroder L.
      • Ruttmann E.
      Is extracorporeal rewarming indicated in avalanche victims with unwitnessed hypothermic cardiorespiratory arrest?.

      Causes of death

      Human retrospective data

      Most avalanche death are caused by asphyxia. In nine studies, the causes of death ranged from 65-100 %
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      • Christensen E.D.
      • Lacsina E.Q.
      Mountaineering fatalities on Mount Rainier, Washington, 1977–1997: autopsy and investigative findings.
      • Blancher M.
      • Bauvent Y.
      • Baré S.
      • et al.
      Multiple casualty incident in the mountain: Experience from the Valfrejus avalanche.
      • McIntosh S.E.
      • Grissom C.K.
      • Olivares C.R.
      • Kim H.S.
      • Tremper B.
      Cause of death in avalanche fatalities.
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Johnson S.M.
      • Johnson A.C.
      • Barton R.G.
      Avalanche trauma and closed head injury: adding insult to injury.
      • Oshiro K.
      • Murakami T.
      Causes of death and characteristics of non-survivors rescued during recreational mountain activities in Japan between 2011 and 2015: a retrospective analysis.
      for asphyxia, 5–29 %
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      • Christensen E.D.
      • Lacsina E.Q.
      Mountaineering fatalities on Mount Rainier, Washington, 1977–1997: autopsy and investigative findings.
      • McIntosh S.E.
      • Grissom C.K.
      • Olivares C.R.
      • Kim H.S.
      • Tremper B.
      Cause of death in avalanche fatalities.
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Johnson S.M.
      • Johnson A.C.
      • Barton R.G.
      Avalanche trauma and closed head injury: adding insult to injury.
      • Oshiro K.
      • Murakami T.
      Causes of death and characteristics of non-survivors rescued during recreational mountain activities in Japan between 2011 and 2015: a retrospective analysis.
      for trauma and 0–4 %
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Oshiro K.
      • Murakami T.
      Causes of death and characteristics of non-survivors rescued during recreational mountain activities in Japan between 2011 and 2015: a retrospective analysis.
      for hypothermia.

      Duration of burial

      Human retrospective data: Retrospective studies

      Epidemiological data show a rapid decrease in the survival probability of critically-buried avalanche victims.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      • Brugger H.
      Falk M.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      • Falk M.
      • Brugger H.
      • Adler-Kastner L.
      Avalanche survival chances.
      In six studies, the survival of critically-buried victims was 93 %
      • Brugger H.
      Falk M.
      • Falk M.
      • Brugger H.
      • Adler-Kastner L.
      Avalanche survival chances.
      at 15 minutes, 91 %
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      at 18 minutes, 28–34 %
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Brugger H.
      • Durrer B.
      • Adler-Kastner L.
      • Falk M.
      • Tschirky F.
      Field management of avalanche victims.
      • Falk M.
      • Brugger H.
      • Adler-Kastner L.
      Avalanche survival chances.
      at 35 minutes, 18 %
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      at 40 minutes, and 25 % at 45 minutes.
      • Brugger H.
      Falk M.
      Among 140 avalanche victims with a burial time ≥ 60 minutes but less than 24 hours, 27 (19 %) survived.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      None of the survivors had CA.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      Short burial duration was associated with higher survival rates
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Hohlrieder M.
      • Thaler S.
      • Wuertl W.
      • et al.
      Rescue missions for totally buried avalanche victims: conclusions from 12 years of experience.
      even in avalanche victims with OHCA,
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      and was associated with higher rates of ROSC before admission.
      • Strapazzon G.
      • Plankensteiner J.
      • Mair P.
      • et al.
      Prehospital management and outcome of avalanche patients with out-of-hospital cardiac arrest: a retrospective study in Tyrol.
      • Ruttmann E.
      • Dietl M.
      • Kastenberger T.
      • et al.
      Characteristics and outcome of patients with hypothermic out-of-hospital cardiac arrest: Experience from a European trauma center.
      The mean duration of burial in those with prehospital ROSC (n = 18) was 27 ± 16 minutes, and the mean time to ROSC from initiation of CPR was 35 ± 20 minutes.
      • Ruttmann E.
      • Dietl M.
      • Kastenberger T.
      • et al.
      Characteristics and outcome of patients with hypothermic out-of-hospital cardiac arrest: Experience from a European trauma center.
      Avalanche accidents occurring at night are rare, but are associated with longer durations of burial and lower probabilities of survival compared with avalanches occurring during the daytime.
      • Rauch S.
      • Koppenberg J.
      • Josi D.
      • et al.
      Avalanche survival depends on the time of day of the accident: A retrospective observational study.

      Human retrospective data: Extreme cases
      • Oberhammer R.
      • Beikircher W.
      • Hörmann C.
      • et al.
      Full recovery of an avalanche victim with profound hypothermia and prolonged cardiac arrest treated by extracorporeal re-warming.
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      • Falk M.
      • Brugger H.
      • Adler-Kastner L.
      Avalanche survival chances.

      Schnee und Lawinen in den Schweizeralpen Winter 1971/72. Winterbericht des Eidgenössischen Instituts für Schnee- und Lawinenforschung, Davos, Switzerland, 1973.

      • Radwin M.I.
      • Grissom C.K.
      Technological advances in avalanche survival.
      • Parry-Jones B.
      • Parry-Jones W.L.
      Post-traumatic stress disorder: supportive evidence from an eighteenth century natural disaster.
      • Gray D.
      Survival after burial in an avalanche.
      • Gasteiger L.
      • Putzer G.
      • Unterpertinger R.
      • et al.
      Solid Organ Donation from Brain Dead Donors with Cardiorespiratory Arrest after Snow Avalanche Burial - A Retrospective Single-Centre Study.
      • Varutti R.
      • Trillo G.
      • Di Silvestre A.
      • et al.
      A case of successful organ donation after extremely prolonged manual cardiopulmonary resuscitation in an avalanche victim.
      • Boué Y.
      • Payen J.F.
      • Torres J.P.
      • Blancher M.
      • Bouzat P.
      Full neurologic recovery after prolonged avalanche burial and cardiac arrest.
      • Kosinski S.
      • Darocha T.
      • Jarosz A.
      • et al.
      The longest persisting ventricular fibrillation with an excellent outcome - 6h 45min cardiac arrest.
      • Locher T.
      • Walpoth B.H.
      Differential diagnosis of circulatory failure in hypothermic avalanche victims: retrospective analysis of 32 avalanche accidents.
      • Dwivedi A.
      • Sharma R.
      • Purkayastha A.
      • Kakria N.
      Imaging findings of a survivor of avalanche without any life support at very high altitude and extreme low temperatures.

      The most extreme reported avalanche cases are reported in Table 2. The longest burial in a CA victim with long (>60 minutes) burial who survived with good neurological outcome was 7 hours.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Boué Y.
      • Payen J.F.
      • Torres J.P.
      • Blancher M.
      • Bouzat P.
      Full neurologic recovery after prolonged avalanche burial and cardiac arrest.
      Table 2The most extreme reported avalanche cases. CA: cardiac arrest; CPB: cardiopulmonary bypass; CPC: cerebral performance category; CPR: cardiopulmonary resuscitation; ECLS: extracorporeal life support; ECMO: extracorporeal membrane oxygenation; PEA: pulseless electrical activity; ROSC: return of spontaneous circulation; VF: ventricular fibrillation.
      Non-CA victims
      Longest burial times for survivors (buried in open areas)
      Case report of a victim extricated after a 6-day burial. The victim later died from trauma (India, 33 yo male).64
      43 hours 45 minutes (Italy, female, age unknown, 1972).

      Schnee und Lawinen in den Schweizeralpen Winter 1971/72. Winterbericht des Eidgenössischen Instituts für Schnee- und Lawinenforschung, Davos, Switzerland, 1973.



      25 hours 30 minutes (Canada, 59 yo male, 1960).
      • Radwin M.I.
      • Grissom C.K.
      Technological advances in avalanche survival.


      17 hours (Switzerland, 21 yo male, 2010).
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      Longest burial time for survivors (inside a building buried in an avalanche)37 days (Italy, two women and a 11 yo child buried in a 2x3 metre cavity inside a building. No CA).
      • Parry-Jones B.
      • Parry-Jones W.L.
      Post-traumatic stress disorder: supportive evidence from an eighteenth century natural disaster.
      CA victims
      Shortest burial duration leading to CA from asphyxia and death10 minutes (France, 29 yo male, no airway obstruction but no air pocket, extricated in CA and died from asphyxia).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.


      10 minutes (Switzerland, age and sex not specified).
      • Brugger H.
      Falk M.
      Longest burial duration leading to CA from asphyxia and survival45 minutes (France, 39 yo male, CPC unfavourable).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.


      20 minutes, (France, 33 yo male, 44 yo male, and 23 yo male, all ROSC on site, all CPC unfavourable).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.


      20 minutes (UK, 32 yo, sex unknown, burial time 20 min, chest compressions, ROSC, CPC 1).
      • Gray D.
      Survival after burial in an avalanche.


      20 minutes (Austria, 26 yo male and 31 yo male, both prehospital ROSC and CPC 4).
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      Shortest burial duration leading to CA from hypothermia and survival100 minutes (Italy, 29 yo male, air pocket, witnessed CA (VF), 21.7 °C, potassium 4.3 mmol/L, ECMO, CPC1).
      • Oberhammer R.
      • Beikircher W.
      • Hörmann C.
      • et al.
      Full recovery of an avalanche victim with profound hypothermia and prolonged cardiac arrest treated by extracorporeal re-warming.
      Longest burial duration leading to CA from asphyxia, ROSC and death60 minutes (France, 29 yo male, 15 minutes CPR, prehospital ROSC).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.


      60 minutes (Austria, 53 yo, sex unknown, prehospital ROSC).
      • Gasteiger L.
      • Putzer G.
      • Unterpertinger R.
      • et al.
      Solid Organ Donation from Brain Dead Donors with Cardiorespiratory Arrest after Snow Avalanche Burial - A Retrospective Single-Centre Study.


      60 minutes (Italy, 41 yo male, ROSC after ECLS, organ donor).
      • Varutti R.
      • Trillo G.
      • Di Silvestre A.
      • et al.
      A case of successful organ donation after extremely prolonged manual cardiopulmonary resuscitation in an avalanche victim.
      Longest burial duration leading to hypothermic CA and survival7 hours (France, 41 yo male, witnessed CA (PEA), ECLS, CPC 1).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Boué Y.
      • Payen J.F.
      • Torres J.P.
      • Blancher M.
      • Bouzat P.
      Full neurologic recovery after prolonged avalanche burial and cardiac arrest.


      See Table 4, Supplemental file 3.
      Longest CPR duration in a survivor5 hours 45 minutes (Poland, 25 yo female, burial time 2 hours, witnessed CA (VF), ECLS, CPC1).
      • Kosinski S.
      • Darocha T.
      • Jarosz A.
      • et al.
      The longest persisting ventricular fibrillation with an excellent outcome - 6h 45min cardiac arrest.
      Longest CPR duration leading to prehospital ROSC.148 minutes (France, 51 yo female, burial time 30 minutes, asystole, potassium 4.7 mmol/L at admission, died).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.


      100 minutes (France, 41 yo female, burial time 40 minutes, PEA, ROSC, potassium 10.4 mmol/L, died).
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      Highest potassium in a survivor of avalanche CA rewarmed with ECLS6.4 mmol/L (Switzerland, age and sex unknown, witnessed CA, burial duration 120 minutes, T° 24.2 °C, CPR duration 108 minutes, CPB, CPC 1).
      • Locher T.
      • Walpoth B.H.
      Differential diagnosis of circulatory failure in hypothermic avalanche victims: retrospective analysis of 32 avalanche accidents.
      a Case report of a victim extricated after a 6-day burial. The victim later died from trauma (India, 33 yo male).
      • Dwivedi A.
      • Sharma R.
      • Purkayastha A.
      • Kakria N.
      Imaging findings of a survivor of avalanche without any life support at very high altitude and extreme low temperatures.

      Airway patency

      In the available data, all survivors to hospital discharge who had cardiac arrest during avalanche burial had patent airways, including hypothermic victims rewarmed with ECLS (Table 3, Supplemental file 5). Only one case report mentioned whether the airway was patent in a victim with short burial. The patient in this case report was successfully resuscitated on site with Basic Life Support (BLS). The airway was patent. The burial duration was 20 minutes and the victim had a respiratory arrest before being successfully resuscitated on site with mouth-to-mouth ventilation (Supplemental file 5).
      • Gray D.
      Survival after burial in an avalanche.
      Because the airway was patent, respiratory arrest may have been caused by compression of the chest by snow.
      • Gray D.
      Survival after burial in an avalanche.
      Usually, asphyxia from airway obstruction is the likely explanation for the clinical course of victims who had ROSC after ventilation. This is supported by the case report of a victim critically buried for 3–5 minutes. There were body parts visible on the surface of the avalanche, but the airway was blocked with compacted snow. There was no CA but the victim developed respiratory distress with pulmonary oedema.
      • Glisenti P.
      • Rakusa J.
      • Albrecht R.
      • Luedi M.M.
      Negative pressure pulmonary oedema with haemorrhage after 5-minute avalanche burial.
      The time to asphyxial CA is variable. In one case with an obstructed airway, asystole occurred after 30 minutes.
      • Heschl S.
      • Paal P.
      • Farzi S.
      • Toller W.
      Electrical cardiac activity in an avalanche victim dying of asphyxia.
      Even if the airway is patent and there is an air pocket, short burial does not guarantee survival.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      Table 3Characteristics of victims of critical avalanche burial and CA at extrication who survived to hospital discharge. Victims in the non-hypothermic (“normothermic”) group include victims with a burial duration ≤ 60 minutes (n = 12), or if burial duration was unknown but the victim was successfully resuscitated on site (n = 3), and victims listed as normothermic by the authors (n = 6). Victims in the hypothermic group include victims with no ROSC on site who underwent hospital extracorporeal life support rewarming and a hypothermic (<30 °C) victim in CA without ROSC on site who survived, even if the rewarming method is unknown.
      • Locher T.
      • Walpoth B.H.
      Differential diagnosis of circulatory failure in hypothermic avalanche victims: retrospective analysis of 32 avalanche accidents.
      Prehospital ROSC was associated with shorter burial times and higher temperatures than without ROSC before admission.
      • Strapazzon G.
      • Plankensteiner J.
      • Mair P.
      • et al.
      Prehospital management and outcome of avalanche patients with out-of-hospital cardiac arrest: a retrospective study in Tyrol.
      • Ruttmann E.
      • Dietl M.
      • Kastenberger T.
      • et al.
      Characteristics and outcome of patients with hypothermic out-of-hospital cardiac arrest: Experience from a European trauma center.
      BLS: basic life support; CA: cardiac arrest; CPC: cerebral performance category; CPR: cardiopulmonary resuscitation; ECLS: extracorporeal life support; IQR: interquartile range; min: minutes; PEA: pulseless electrical activity; ROSC: return of spontaneous circulation.
      Missing dataOverall

      (n = 35)
      Hypothermic CA

      (n = 14)
      Non-hypothermic CA

      (n = 21)
      p value
      Age (years), median (IQR)1632 (25–41)33 (24–41)32 (26–40)0.68
      Wilcoxon rank-sum (Mann-Whitney) test.
      Age (years), range1617–4917–4223–49-
      Burial duration (min), median (IQR)1520 (20–128)143 (120–330)20 (15–20)<0.001
      Wilcoxon rank-sum (Mann-Whitney) test.
      Burial duration (min), range1510–420100–42010–45-
      Temperature (°C), median (IQR)2024 (22–27)22 (21.7–24)26.5 (26–29.3)0.007
      Wilcoxon rank-sum (Mann-Whitney) test.
      Temperature (°C), range2016.9–3416.9–26.926
      All with short (≤45 min) burial duration.
      -34
      Airways patent, n (%)2411 (100 %)11 (100 %).-
      Air pocket present, n (%)255/10 (50 %)5/5 (100 %)0/5 (0 %)0.008
      Fisher exact test.
      Witnessed cardiac arrest, n (%)199/16 (56 %)9/10 (90 %)0/6 (0 %)0.001
      Fisher exact test.
      CA rhythm, n (%)22130.021
      Fisher exact test.
      Ventricular fibrillation550
      PEA110
      Asystole725
      ROSC after BLS, n (%)119/24 (38 %)0/10 (0 %)9/14 (64 %)0.002
      Fisher exact test.
      Prehospital ROSC, n (%)318/32 (56 %)0/14 (0 %)18/18 (100 %)0.000
      Fisher exact test.
      Rewarming method, n (%)2312-
      ECLS1111NA
      Thoracotomy and continuous irrigation11NA
      CPC 1–2, n (%)417/31 (55 %)10/12 (83 %)7/19 (37 %)0.024
      Fisher exact test.
      a All with short (≤45 min) burial duration.
      b Fisher exact test.
      c Wilcoxon rank-sum (Mann-Whitney) test.
      Table 4Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom) for the on-site treatment of avalanche victims. The evidence and strength of the recommendations are graded using the American College of Chest Physicians grading system.
      General actions
      Companions should locate and extricate buried victims as quickly as possible (1B).
      Professional rescue should be mobilised early (1B).
      Duration of burial and airway patency
      For victims with burial time of ≤ 60 minutes without signs of life, presume asphyxia and provide rescue breaths as soon as possible regardless of airway patency (1A).
      If the burial time is > 60 minutes, airway patency should be determined when the face is exposed (1A).
      The possibility of hypothermic CA should be considered for victims with a burial time of > 60 minutes without signs of life but a patent or airway of unknown patency. Unless core temperature can be measured to exclude hypothermic CA, the victim should be resuscitated and transported to a hospital with ECLS rewarming capability (1C).
      Air pocket
      A victim with patent or airway of unknown patency and an air pocket should be resuscitated unless resuscitation would otherwise not be attempted (1C).
      Snow density
      Information about snow density should not be used to change management of the victim (1C).
      Burial depth
      Information about burial depth should not be used to change management of the victim (1C).
      Core temperature measurement
      A timely core temperature measurement is recommended in victims buried for > 60 minutes with a patent airway and no signs of life (1C).
      Oesophageal temperature with the tip of the probe inserted into the lower third of the oesophagus is the preferred method of core temperature measurement in victims in CA or with a secured airway (1C).
      Core temperature should be used instead of burial duration to determine if a victim with a patent or airway of unknown airway patency without signs of life has had a hypothermic CA (1C).
      Victims without signs of life, with a patent airway, and a core temperature < 30 °C should be resuscitated and transported to a hospital with ECLS rewarming capabilities (1B).
      Core temperature is not useful to predict the outcomes of victims with asystolic CA buried > 60 minutes, without signs of life and with an obstructed airway (1C).
      Hypothermic CA may be considered, at the rescuer's discretion, despite a burial duration of ≤ 60 minutes in a victim with a patent airway and no signs of life when there is the possibility of very rapid cooling because of inadequate clothing, a lean victim, an environment favourable to rapid cooling, or burial after physical exertion (2C).
      Cardiac arrest type
      For victims buried > 60 minutes without signs of life, electrocardiographic (ECG) monitoring, ideally using defibrillator pads ready to defibrillate, should be started as soon as the thorax is accessible and ideally before moving the victim (1C).
      The possibility of hypothermic CA should be considered for victims buried > 60 minutes without signs of life with VF or pulseless electrical activity (PEA) regardless of airway patency. Unless core temperature can be measured to exclude hypothermic CA, the victim should be resuscitated and transported to a hospital with ECLS rewarming capabilities (1B).
      Resuscitation should not be attempted on victims with an obstructed airway in asystole, who have been buried for > 60 minutes (1A).
      For victims buried > 60 minutes, carefully check for signs of life, including vital signs, for up to one minute (1B).
      Hypothermia should be considered as a likely cause of CA in victims buried > 60 minutes when there is a witnessed CA. Unless a core temperature can be measured to exclude hypothermic CA, the victim should be resuscitated and transported to a hospital with ECLS rewarming capability (1A).
      Trauma should be considered as a likely cause of witnessed CA for victims buried ≤ 60 minutes or with a core temperature > 30 °C (1B).
      Rescuers should consider the poor prognosis of victims buried > 60 minutes with unwitnessed cardiac arrest and asystole. Rescuers may decide to withhold CPR under these circumstances especially in a difficult rescue or when resources are limited at the scene (2B).
      For victims with burial time of ≤ 60 minutes without signs of life, presume asphyxia and provide rescue breaths as soon as possible regardless of airway patency (2B).
      Chest compressions can be provided effectively even in atypical position before complete extrication (2A).
      Trauma
      Severe trauma should be suspected in avalanches in steep terrain with rocks and trees. When severe trauma is suspected, on-site trauma treatment should be started as soon as possible according to international trauma guidelines (1C).
      Rescuers should provide spinal motion restriction when indicated during extrication, packaging, and transportation of avalanche victims (1C).
      Trauma should be considered as a potential cause of CA in avalanche victims (1B).
      For victims without signs of life and with a patent airway buried > 60 minutes or with a temperature < 30 °C, chest decompression should be considered only in cases of clinically suspected chest trauma (1C).
      Negative pressure pulmonary edema
      A victim with a critical burial and signs or symptoms of respiratory distress at extrication, should be considered to have pulmonary oedema and should be admitted to an appropriate hospital (1B).
      A victim with critical burial should be transported to the nearest emergency department for advanced assessment and observation (1C).
      In-hospital rewarming
      In-hospital prediction of successful rewarming in an avalanche victim should include the estimation of the survival probability using the HOPE score (1C).
      Hypothermia should be considered as a likely cause of CA for a victim buried > 60 minutes with a witnessed CA. In this case, the HOPE score should be calculated using the non-asphyxia scenario (1A).
      If there is a possibility that an avalanche victim may not have been asphyxiated despite full burial, calculating the HOPE score using the non-asphyxia scenario will decrease the risk of underestimating the probability of survival after rewarming (1C).
      If the HOPE score cannot be determined, the combination of a potassium < 7 mmol/L and a temperature < 30 °C may be used instead to indicate the need for ECLS rewarming (1C).
      Non-avalanche-specific recommendations
      Management of associated medical conditions such as hypothermia, normothermic CA, trauma, and termination of CPR) should follow the most current guidelines (1A).

      Air pocket

      Human retrospective data

      The presence of an air pocket is associated with increased survival.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      The absence of air pockets in victims with patent airways who survived CA with burial times ≤ 45 minutes is associated with unfavourable neurological outcomes (Supplemental file 5). An air pocket may also be present in victims with fatal injuries.
      • Eidenbenz D.
      • Techel F.
      • Kottmann A.
      • et al.
      Survival probability in avalanche victims with long burial (≥60 min): A retrospective study.
      Severe asphyxia may occur despite the presence of an air pocket.
      • Paal P.
      • Strapazzon G.
      • Braun P.
      • et al.
      Factors affecting survival from avalanche burial–a randomised prospective porcine pilot study.
      • Strapazzon G.
      • Paal P.
      • Schweizer J.
      • et al.
      Effects of snow properties on humans breathing into an artificial air pocket - an experimental field study.
      Connection of the air pocket with the outside may be associated with a better outcome.
      • Koppenberg J.
      • Brugger H.
      • Esslinger A.
      Albrecht R.
      An air pocket of 15x15x15 cm was present for a victim with long burial who had an undetected rescue collapse and died.
      • Strapazzon G.
      • Beikircher W.
      • Procter E.
      • Brugger H.
      Electrical heart activity recorded during prolonged avalanche burial.
      Victims with air pockets are more likely to survive, especially when buried > 15 minutes.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      In victims with burial times ≤ 15 minutes, survival was 95 % with an air pocket and 69 % without an air pocket (p < 0.001). In victims with burial times > 15 minutes, survival was 67 % with an air pocket and 4 % without (p < 0.001). Three survivors with no air pocket were buried for 20, 25 and 120 minutes. Survival may be possible despite long burial and absence of an air pocket.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.

      Prospective experimental studies:

      Studies on human volunteers buried in snow, breathing into artificial 4 L air pockets found a rapid decline in arterial oxygen saturation (SpO2) and an increase in end-tidal carbon dioxide (EtCO2).
      • Strapazzon G.
      • Paal P.
      • Schweizer J.
      • et al.
      Effects of snow properties on humans breathing into an artificial air pocket - an experimental field study.
      Another study found a greater decrease in SpO2 at 4 minutes (p = 0.013) with a small (1L) air pocket compared with a large air pocket (2L). The increase in EtCO2 at 4 minutes did not correlate with air pocket size.
      • Brugger H.
      • Sumann G.
      • Meister R.
      • et al.
      Hypoxia and hypercapnia during respiration into an artificial air pocket in snow: implications for avalanche survival.
      Compared with the absence of an air pocket, the presence of a small (1L) air pocket significantly reduced the effort of breathing (p < 0.05), the decrease in SpO2 (p < 0.05), and the increase in EtCO2 (p < 0.05).
      • Roubík K.
      • Sieger L.
      • Sykora K.
      Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study.
      Using an Avalung™, a device that creates and artificial air pocket, resulted in a smaller decrease in SpO2 and a smaller increase in EtCO2 and partial pressure of inspired CO2 (PiCO2) when compared with breathing into a 500 cm
      • Brugger H.
      • Durrer B.
      • Elsensohn F.
      • et al.
      Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel.
      air pocket.
      • Grissom C.K.
      • Radwin M.I.
      • Harmston C.H.
      • Hirshberg E.L.
      • Crowley T.J.
      Respiration during snow burial using an artificial air pocket.
      The use of a different artificial air pocket device (Ferrino Airsafe™) was associated with a slower fall in SpO2, allowing for increased burial time when compared with breathing into a 1L air pocket.
      • Strapazzon G.
      • Malacrida S.
      • Governo E.
      • et al.
      An artificial air pocket device reduces inspired level of carbon dioxide in participants completely buried in avalanche debris: an experimental, randomized crossover study.
      The administration of air through a tube in front of the face of volunteers buried in a simulated avalanche with an air pocket was associated with higher SpO2 and lower EtCO2 (p < 0.05) compared with the absence of air administration.
      • Wik L.
      • Brattebo G.
      • Osteras O.
      • et al.
      Physiological effects of providing supplemental air for avalanche victims.
      An animal study with piglets buried in snow, simulating avalanche burial, breathing either into an air pocket (1 or 2 L) or ambient air found that the time to asystole was shorter in the air pocket group compared to the ambient air group (p = 0.025). This suggests that severe asphyxia can occur despite the presence of an air pocket.
      • Paal P.
      • Strapazzon G.
      • Braun P.
      • et al.
      Factors affecting survival from avalanche burial–a randomised prospective porcine pilot study.
      Hypercapnia was likely the main cause of cardiovascular instability, which was likely the main cause of decreased cerebral oxygenation despite severe hypothermia.
      • Strapazzon G.
      • Putzer G.
      • Dal Cappello T.
      • et al.
      Effects of hypothermia, hypoxia, and hypercapnia on brain oxygenation and hemodynamic parameters during simulated avalanche burial: a porcine study.
      Severe hypercapnia might also limit the hypothermia-related beneficit of increased oxygen uptake in the lungs.
      • Woyke S.
      • Brugger H.
      • Ströhle M.
      • et al.
      Effects of Carbon Dioxide and Temperature on the Oxygen-Hemoglobin Dissociation Curve of Human Blood: Implications for Avalanche Victims.

      Snow density

      Studies of human volunteers breathing into artificial air pockets showed that higher snow densities are associated with more rapid declines in SpO2 and increases in EtCO2.
      • Brugger H.
      • Sumann G.
      • Meister R.
      • et al.
      Hypoxia and hypercapnia during respiration into an artificial air pocket in snow: implications for avalanche survival.
      • Strapazzon G.
      • Paal P.
      • Schweizer J.
      • et al.
      Effects of snow properties on humans breathing into an artificial air pocket - an experimental field study.
      In high snow densities, cerebral venous oxygen saturation (ScO2) measured by near-infrared spectroscopy (NIRS) showed significant decreases.
      • Strapazzon G.
      • Gatterer H.
      • Falla M.
      • et al.
      Hypoxia and hypercapnia effects on cerebral oxygen saturation in avalanche burial: A pilot human experimental study.

      Burial depth

      Burial depth should be measured at the head of the victim. Greater burial depth is associated with higher mortality,
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      • Armstrong B.R.
      AVALANCHE ACCIDENT VICTIMS IN THE USA.
      • Brugger H.
      Falk M.
      independent of the duration of burial.
      • Procter E.
      • Strapazzon G.
      • Dal Cappello T.
      • et al.
      Burial duration, depth and air pocket explain avalanche survival patterns in Austria and Switzerland.
      There was one survivor without CA after a 2.5 m deep burial
      • Gasteiger L.
      • Putzer G.
      • Unterpertinger R.
      • et al.
      Solid Organ Donation from Brain Dead Donors with Cardiorespiratory Arrest after Snow Avalanche Burial - A Retrospective Single-Centre Study.
      and another survivor, despite CA, at 7 m in a victim buried by snow in a crevasse.
      • Althaus U.
      • Aeberhard P.
      • Schupbach P.
      • Nachbur B.H.
      • Muhlemann W.
      Management of profound accidental hypothermia with cardiorespiratory arrest.

      Core temperature measurement

      The most accurate core temperature measurement in CA victims is oesophageal temperature, with the distal tip of the probe in the lower third of the oesophagus.
      • Paal P.
      • Gordon L.
      • Strapazzon G.
      • et al.
      Accidental hypothermia-an update : The content of this review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).
      • Pasquier M.
      • Paal P.
      • Kosinski S.
      • et al.
      Esophageal Temperature Measurement.
      • Dow J.
      • Giesbrecht G.G.
      • Danzl D.F.
      • et al.
      Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update.
      • Lott C.
      • Truhlář A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      Esophageal temperature measurement is the preferred method in intubated victims and in victims with supraglottic airway devices with a gastric channel.
      • Paal P.
      • Gordon L.
      • Strapazzon G.
      • et al.
      Accidental hypothermia-an update : The content of this review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).
      • Dow J.
      • Giesbrecht G.G.
      • Danzl D.F.
      • et al.
      Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update.
      • Lott C.
      • Truhlář A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      Epitympanic measurement, if available, may also be used in non-intubated victims who are not in CA.
      • Paal P.
      • Gordon L.
      • Strapazzon G.
      • et al.
      Accidental hypothermia-an update : The content of this review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).
      • Dow J.
      • Giesbrecht G.G.
      • Danzl D.F.
      • et al.
      Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update.
      • Lott C.
      • Truhlář A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      In two case reports of survivors of witnessed CA following critical burials of 6 and 7 hours, the cooling rates were estimated at 2.3 and 1.8 °C/h.
      • Boué Y.
      • Payen J.F.
      • Torres J.P.
      • Blancher M.
      • Bouzat P.
      Full neurologic recovery after prolonged avalanche burial and cardiac arrest.
      The published cooling rates for critically buried victims not in CA is variable, ranging from low values between 0.3 and 0.6 °C/h
      • Facchetti G.
      • Avancini G.
      • Aloisio L.
      • et al.
      Low cooling rate in avalanche burial: Two case reports.
      to much higher values, of 5.1 °C/h,
      • Strapazzon G.
      • Putzer G.
      • Dal Cappello T.
      • et al.
      Effects of hypothermia, hypoxia, and hypercapnia on brain oxygenation and hemodynamic parameters during simulated avalanche burial: a porcine study.
      • Strapazzon G.
      • Nardin M.
      • Zanon P.
      • et al.
      Respiratory failure and spontaneous hypoglycemia during noninvasive rewarming from 24.7°C (76.5°F) core body temperature after prolonged avalanche burial.
      6 °C/h,
      • Putzer G.
      • Schmid S.
      • Braun P.
      • Brugger H.
      • Paal P.
      Cooling of six centigrades in an hour during avalanche burial.
      or 8.5 °C/h
      • Mittermair C.
      • Foidl E.
      • Wallner B.
      • Brugger H.
      • Paal P.
      Extreme Cooling Rates in Avalanche Victims: Case Report and Narrative Review.
      An extreme cooling rate of 9.4 °C/h was measured in a lightly dressed victim in a very cold environment who was extricated in CA.
      • Pasquier M.
      • Moix P.A.
      • Delay D.
      • Hugli O.
      Cooling rate of 9.4 °C in an hour in an avalanche victim.
      A rate of 7 °C/h was measured in a partially buried victim.
      • Ströhle M.
      • Putzer G.
      • Procter E.
      • Paal P.
      Apparent Cooling Rate of 7°C per Hour in an Avalanche Victim.
      A systematic review of hypothermic victims with witnessed CA suggested that hypothermia alone is unlikely to be the sole cause of CA if core temperature is > 30 °C.
      • Frei C.
      • Darocha T.
      • Debaty G.
      • et al.
      Clinical characteristics and outcomes of witnessed hypothermic cardiac arrest: A systematic review on rescue collapse.
      In addition to hypothermia, hypercapnia and hypoxia have roles in the pathophysiology of CA in avalanche victims.
      • Paal P.
      • Strapazzon G.
      • Braun P.
      • et al.
      Factors affecting survival from avalanche burial–a randomised prospective porcine pilot study.
      • Strapazzon G.
      • Putzer G.
      • Dal Cappello T.
      • et al.
      Effects of hypothermia, hypoxia, and hypercapnia on brain oxygenation and hemodynamic parameters during simulated avalanche burial: a porcine study.
      • Strapazzon G.
      • Gatterer H.
      • Falla M.
      • et al.
      Hypoxia and hypercapnia effects on cerebral oxygen saturation in avalanche burial: A pilot human experimental study.

      Cardiac arrest type

      CA rhythm

      The most frequent initial cardiac rhythm in a hypothermic survivor of CA following an avalanche accident is ventricular fibrillation (VF). Asystole is the most frequent initial cardiac rhythm in non-hypothermic victims (Table 3).
      • Mair P.
      • Brugger H.
      • Mair B.
      • Moroder L.
      • Ruttmann E.
      Is extracorporeal rewarming indicated in avalanche victims with unwitnessed hypothermic cardiorespiratory arrest?.
      Asystole can be the presenting rhythm in hypothermic CA, but in avalanche victims, hypothermic asystolic CA is rare (Table 3) and is associated with poor outcomes.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Frei C.
      • Darocha T.
      • Debaty G.
      • et al.
      Clinical characteristics and outcomes of witnessed hypothermic cardiac arrest: A systematic review on rescue collapse.

      Witnessed and unwitnessed CA

      Witnessed CA in an avalanche victim is associated with increased survival.
      • Boué Y.
      • Payen J.F.
      • Brun J.
      • et al.
      Survival after avalanche-induced cardiac arrest.
      • Mair P.
      • Brugger H.
      • Mair B.
      • Moroder L.
      • Ruttmann E.
      Is extracorporeal rewarming indicated in avalanche victims with unwitnessed hypothermic cardiorespiratory arrest?.
      If traumatic CA is excluded, witnessed CA is common in hypothermic CA following a long burial (Table 3). Vital signs may be faint and difficult to detect in deep hypothermia. Rescuers should check for signs of life, including vital signs, for up to one minute before diagnosing CA if deep hypothermia (<30 °C) is suspected.
      • Lott C.
      • Truhlar A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      • Musi M.E.
      • Sheets A.
      • Zafren K.
      • et al.
      Clinical staging of accidental hypothermia: The Revised Swiss System: Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom).
      A victim buried > 60 minutes with unwitnessed cardiac arrest and asystole has a low probability of survival. We found only one report of a survivor with unwitnessed CA following long burial and hypothermic CA. The presenting rhythm was asystole (Table 3).
      • Althaus U.
      • Aeberhard P.
      • Schupbach P.
      • Nachbur B.H.
      • Muhlemann W.
      Management of profound accidental hypothermia with cardiorespiratory arrest.
      CA may occur but be clinically undetected when the victim is extricated.
      • Strapazzon G.
      • Beikircher W.
      • Procter E.
      • Brugger H.
      Electrical heart activity recorded during prolonged avalanche burial.
      • Frei C.
      • Darocha T.
      • Debaty G.
      • et al.
      Clinical characteristics and outcomes of witnessed hypothermic cardiac arrest: A systematic review on rescue collapse.
      This may have occurred in one victim with a patent airway and an air pocket who was extricated after a burial of 253 minutes.
      • Strapazzon G.
      • Beikircher W.
      • Procter E.
      • Brugger H.
      Electrical heart activity recorded during prolonged avalanche burial.
      No CPR was provided but the victim was later shown by the post-mortem analysis of the data on his multifunction sport watch to have had a CA at the time of extrication.
      • Strapazzon G.
      • Beikircher W.
      • Procter E.
      • Brugger H.
      Electrical heart activity recorded during prolonged avalanche burial.

      Time between locating a victim and the start of BLS

      Most critically buried victims are not in a horizontal supine position when found. In one study of 159 critically buried avalanche victims, the head was lower than the body in 65 % of the victims.
      • Kornhall D.K.
      • Logan S.
      • Dolven T.
      Body Positioning of Buried Avalanche Victims.
      Forty-five percent of the victims were in the prone position, 24 % supine, 16 % sitting or standing, and 15 % lying on their sides.
      • Kornhall D.K.
      • Logan S.
      • Dolven T.
      Body Positioning of Buried Avalanche Victims.
      In a simulation study, the median time from the location of a critically buried victim to airway access was 7.2 minutes and the median time to supine position for CPR was 10.1 minutes.
      • Wallner B.
      • Moroder L.
      • Brandt A.
      • et al.
      Extrication Times During Avalanche Companion Rescue: A Randomized Single-Blinded Manikin Study.
      Chest compressions can be provided effectively by lay rescuers, before complete extrication, even in atypical positions. This may reduce the time to CPR in avalanche rescue.
      • Wallner B.
      • Moroder L.
      • Salchner H.
      • et al.
      CPR with restricted patient access using alternative rescuer positions: a randomised cross-over manikin study simulating the CPR scenario after avalanche burial.
      • Wallner B.
      • Strapazzon G.
      • Brugger H.
      Is there any reason for prone cardiopulmonary resuscitation in avalanche victims?.
      The quality of ventilation provided by lay rescuers using mouth to mouth ventilation or using a pocket mask is generally poor.
      • Wallner B.
      • Moroder L.
      • Salchner H.
      • et al.
      CPR with restricted patient access using alternative rescuer positions: a randomised cross-over manikin study simulating the CPR scenario after avalanche burial.
      In victims with very short burial times (≤20 minutes) extricated in CA, ROSC after BLS and survival with good outcome is possible (Supplemental file 5).
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      • Gray D.
      Survival after burial in an avalanche.
      • Locher T.
      • Walpoth B.H.
      Differential diagnosis of circulatory failure in hypothermic avalanche victims: retrospective analysis of 32 avalanche accidents.
      • Dorn W.
      • Matter P.
      Case reports of Davos avalanche accidents 1972/73-1987/88.
      • Grossman M.D.
      • Saffle J.R.
      • Thomas F.
      • Tremper B.
      Avalanche trauma.
      We found nine such cases of ROSC on site after BLS (Supplemental file 5).
      • Moroder L.
      • Mair B.
      • Brugger H.
      • Voelckel W.
      • Mair P.
      Outcome of avalanche victims with out-of-hospital cardiac arrest.
      • Gray D.
      Survival after burial in an avalanche.
      • Locher T.
      • Walpoth B.H.
      Differential diagnosis of circulatory failure in hypothermic avalanche victims: retrospective analysis of 32 avalanche accidents.
      • Dorn W.
      • Matter P.
      Case reports of Davos avalanche accidents 1972/73-1987/88.
      • Grossman M.D.
      • Saffle J.R.
      • Thomas F.
      • Tremper B.
      Avalanche trauma.
      The clinical course of these victims was compatible with CA from asphyxia and successful resuscitation after restoration of ventilation and oxygenation. A case reported 40 years ago described a victim who was extricated in asystole after being critically buried for 5 h. He survived without sequelae despite a no-flow time of 70 minutes after extrication.
      • Althaus U.
      • Aeberhard P.
      • Schupbach P.
      • Nachbur B.H.
      • Muhlemann W.
      Management of profound accidental hypothermia with cardiorespiratory arrest.

      Trauma

      Trauma is a significant cause of death in fatal avalanche accidents. In Canada, trauma accounted for 19 % of fatalities in one study
      • Haegeli P.
      • Falk M.
      • Brugger H.
      • Etter H.J.
      • Boyd J.
      Comparison of avalanche survival patterns in Canada and Switzerland.
      and 24 %
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      of fatalities in another study. In other studies, the percentage of fatalities caused by trauma was 6 % in Austria,
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      5 %
      • McIntosh S.E.
      • Grissom C.K.
      • Olivares C.R.
      • Kim H.S.
      • Tremper B.
      Cause of death in avalanche fatalities.
      and 29 % in the USA,
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      and 15 % in Japan.
      • Oshiro K.
      • Murakami T.
      Causes of death and characteristics of non-survivors rescued during recreational mountain activities in Japan between 2011 and 2015: a retrospective analysis.
      Trauma may be severe.
      • Mair P.
      • Frimmel C.
      • Vergeiner G.
      • et al.
      Emergency medical helicopter operations for avalanche accidents.
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Oshiro K.
      • Murakami T.
      Causes of death and characteristics of non-survivors rescued during recreational mountain activities in Japan between 2011 and 2015: a retrospective analysis.
      • Ströhle M.
      • Putzer G.
      • Procter E.
      • Paal P.
      Apparent Cooling Rate of 7°C per Hour in an Avalanche Victim.
      • Wick M.C.
      • Weiss R.J.
      • Hohlrieder M.
      • et al.
      Radiological aspects of injuries of avalanche victims.
      Injuries may include head injuries
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Özkaçmaz S.
      • Dündar İ.
      • Çoban L.T.
      • et al.
      Radiological imaging findings of avalanche victims with traumatic lesions in Van Eastern Province of Turkey.
      chest injuries,
      • Boyd J.
      • Haegeli P.
      • Abu-Laban R.B.
      • Shuster M.
      • Butt J.C.
      Patterns of death among avalanche fatalities: a 21-year review.
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      • Cohen J.G.
      • Boué Y.
      • Boussat B.
      • et al.
      Serum potassium concentration predicts brain hypoxia on CT after avalanche-induced cardiac arrest.
      including pneumothorax,
      • Dwivedi A.
      • Sharma R.
      • Purkayastha A.
      • Kakria N.
      Imaging findings of a survivor of avalanche without any life support at very high altitude and extreme low temperatures.
      • Ströhle M.
      • Putzer G.
      • Procter E.
      • Paal P.
      Apparent Cooling Rate of 7°C per Hour in an Avalanche Victim.
      • Wick M.C.
      • Weiss R.J.
      • Hohlrieder M.
      • et al.
      Radiological aspects of injuries of avalanche victims.
      • Özkaçmaz S.
      • Dündar İ.
      • Çoban L.T.
      • et al.
      Radiological imaging findings of avalanche victims with traumatic lesions in Van Eastern Province of Turkey.
      • Stalsberg H.
      • Albretsen C.
      • Gilbert M.
      • et al.
      Mechanism of death in avalanche victims.
      unstable spinal injuries, and pelvic fractures.
      • Hohlrieder M.
      • Brugger H.
      • Schubert H.M.
      • et al.
      Pattern and severity of injury in avalanche victims.
      • Sheets A.
      • Wang D.
      • Logan S.
      • Atkins D.
      Causes of Death Among Avalanche Fatalities in Colorado: A 21-Year Review.
      • Grosse A.B.
      • Grosse C.A.
      • Steinbach L.S.
      • Zimmermann H.
      • Anderson S.
      Imaging findings of avalanche victims.
      • Özkaçmaz S.
      • Dündar İ.
      • Çoban L.T.
      • et al.
      Radiological imaging findings of avalanche victims with traumatic lesions in Van Eastern Province of Turkey.
      • Cohen J.G.
      • Boué Y.
      • Boussat B.
      • et al.
      Serum potassium concentration predicts brain hypoxia on CT after avalanche-induced cardiac arrest.
      • Grosse A.B.
      • Grosse C.A.
      • Steinbach L.S.
      • Zimmermann H.
      • Anderson S.
      Imaging findings of avalanche victims.
      • Kobek M.
      • Skowronek R.
      • Jabłoński C.
      • Jankowski Z.
      • Pałasz A.
      Histopathological changes in lungs of the mountain snow avalanche victims and its potential usefulness in determination of cause and mechanism of death.
      Frostbite can also occur.

      Schnee und Lawinen in den Schweizeralpen Winter 1971/72. Winterbericht des Eidgenössischen Instituts für Schnee- und Lawinenforschung, Davos, Switzerland, 1973.

      • Grosse A.B.
      • Grosse C.A.
      • Steinbach L.S.
      • Zimmermann H.
      • Anderson S.
      Imaging findings of avalanche victims.
      Severe trauma may be suspected on site but not found at autopsy
      • Geisenberger D.
      • Kramer L.
      • Pircher R.
      Pollak S.
      or severe trauma may not be detected on site but found later in hospital. Invasive procedures, such as thoracostomies, may precipitate bleeding and complicate rewarming with ECLS in hypothermic CA victims.
      • Swol J.
      • Darocha T.
      • Paal P.
      • et al.
      Extracorporeal Life Support in Accidental Hypothermia with Cardiac Arrest-A Narrative Review.
      • Jarosz A.
      • Kosinski S.
      • Darocha T.
      • et al.
      Problems and Pitfalls of Qualification for Extracorporeal Rewarming in Severe Accidental Hypothermia.

      Negative pressure pulmonary oedema

      Pulmonary oedema, thought to be caused by negative pressure, has been described in critically buried avalanche victims, usually occurring in victims with short burial durations. Pulmonary oedema can occur in burials as short as 3–5 minutes.
      • Ouzzani M.
      • Hammady H.
      • Fedorowicz Z.
      • Elmagarmid A.
      Rayyan-a web and mobile app for systematic reviews.
      • Glisenti P.
      • Rakusa J.
      • Albrecht R.
      • Luedi M.M.
      Negative pressure pulmonary oedema with haemorrhage after 5-minute avalanche burial.
      • Aydin Y.
      • Ogul H.
      • Araz O.
      • Eroglu A.
      A rare cause of pulmonary oedema: buried under an avalanche.
      • Schmid F.
      The pathogenesis of pulmonary edema after being buried by an avalanche.
      • Sumann G.
      • Putzer G.
      • Brugger H.
      • Paal P.
      Pulmonary edema after complete avalanche burial.
      Although pulmonary oedema requires hospitalisation, generally with non-invasive ventilation or intubation, it usually resolves with treatment within 24 hours.
      • Glisenti P.
      • Rakusa J.
      • Albrecht R.
      • Luedi M.M.
      Negative pressure pulmonary oedema with haemorrhage after 5-minute avalanche burial.
      • Sumann G.
      • Putzer G.
      • Brugger H.
      • Paal P.
      Pulmonary edema after complete avalanche burial.

      Avalanche-specific recommendations (Table 4)

      The initial management of critically buried avalanche victims and decision-making for advanced management of critically buried avalanche victims in CA are summarised in two separate algorithms (Fig. 2 and Fig. 3). We have revised the Avalanche Victim Resuscitation Checklist (AVRC), based on the updated algorithms, for clinical decision support and documentation in the field (Supplemental file 6).
      • Kottmann A.
      • Blancher M.
      • Pasquier M.
      • Brugger H.
      Avalanche Victim Resuscitation Checklist adaption to the 2015 ERC Resuscitation guidelines.
      Figure thumbnail gr2
      Fig. 2Initial management of critically buried avalanche victims.
      Figure thumbnail gr3
      Fig. 3Decision-making algorithm for advanced management of critically buried avalanche victims in cardiac arrest.

      In-hospital rewarming

      The decision whether to perform ECLS rewarming in-hospital for hypothermic avalanche victims in CA has traditionally been based on the serum potassium, or, more recently, using a combination of potassium (7 mmol/L) and temperature (30 °C) cutoffs.
      • Brugger H.
      • Durrer B.
      • Elsensohn F.
      • et al.
      Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel.
      • Brugger H.
      • Bouzat P.
      • Pasquier M.
      • et al.
      Cut-off values of serum potassium and core temperature at hospital admission for extracorporeal rewarming of avalanche victims in cardiac arrest: A retrospective multi-centre study.
      This approach has recently changed. The 2021 ERC guidelines no longer advise the use of a single potassium value as a primary triage tool, but rather as part of a multivariable tool such as the Hypothermia Outcome Prediction score after ECLS (HOPE) score. Alternatively, the combination of a potassium < 7 mmol/L and a temperature < 30 °C indicates a need for ECLS.
      • Lott C.
      • Truhlar A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      • Brugger H.
      • Bouzat P.
      • Pasquier M.
      • et al.
      Cut-off values of serum potassium and core temperature at hospital admission for extracorporeal rewarming of avalanche victims in cardiac arrest: A retrospective multi-centre study.
      • Pasquier M.
      • Hugli O.
      • Paal P.
      • et al.
      Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: The HOPE score.
      Having the head fully covered by snow is defined in the HOPE derivation and validation studies as an asphyxia-related mechanism, linked to lower survival probability.
      • Pasquier M.
      • Hugli O.
      • Paal P.
      • et al.
      Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: The HOPE score.
      • Pasquier M.
      • Rousson V.
      • Darocha T.
      • et al.
      Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score.
      Because there were few avalanche victims in the HOPE validation study (fewer than 10 survivors after ECLS rewarming with avalanche burial), the HOPE score should be used cautiously, especially if there is doubt about the reliability of airway patency. In case of uncertainty, other parameters should be considered, such as cooling after extrication, clothing, asociated trauma, and laboratory parameters, including pH, lactate, and coagulopathy. If there is a possibility that an avalanche victim may not have been asphyxiated despite critical burial or for a victim buried > 60minutes and who had a witnessed CA, calculating the HOPE score using the non-asphyxia scenario will decrease the risk of underestimating the probability of survival and choosing not to provide ECLS rewarming despite a potentially favourable survival probability.

      Non-avalanche-specific recommendations

      There are guidelines for the management of medical conditions that may occur in avalanche victims, that are not specific to, avalanche victims. This is the case for accidental hypothermia,
      • Lott C.
      • Truhlar A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      • Musi M.E.
      • Sheets A.
      • Zafren K.
      • et al.
      Clinical staging of accidental hypothermia: The Revised Swiss System: Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom).
      • Paal P.
      • Gordon L.
      • Strapazzon G.
      • et al.
      Accidental hypothermia-an update : The content of this review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).
      • Dow J.
      • Giesbrecht G.G.
      • Danzl D.F.
      • et al.
      Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update.
      normothermic CA, trauma,
      • Lott C.
      • Truhlar A.
      • Alfonzo A.
      • et al.
      European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.
      • Sumann G.
      • Moens D.
      • Brink B.
      • et al.
      Multiple trauma management in mountain environments - a scoping review : Evidence based guidelines of the International Commission for Mountain Emergency Medicine (ICAR MedCom). Intended for physicians and other advanced life support personnel. Scand J Trauma Resusc.
      and termination of CPR.
      • Schon C.A.
      • Gordon L.
      • Holzl N.
      • et al.
      Determination of Death in Mountain Rescue: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom).

      Limitations

      A major limitation of the present work is that most data supporting the recommendations are retrospective. The number of reported survivors is low. Prospective collection of high-quality data, including use of dedicated registries, would be useful. We did not address multiple triage situations.
      • Bogle L.B.
      • Boyd J.J.
      • McLaughlin K.A.
      Triaging multiple victims in an avalanche setting: the Avalanche Survival Optimizing Rescue Triage algorithmic approach.
      • Genswein M.
      • Macias D.
      • McIntosh S.
      • et al.
      AvaLife—A New Multi-Disciplinary Approach Supported by Accident and Field Test Data to Optimize Survival Chances in Rescue and First Aid of Avalanche Patients.
      Although organ donation by brain-dead avalanche victims was not included in the analysis when formulating the recommendations, it may be an important consideration.
      • Métrailler-Mermoud J.
      • Hugli O.
      • Carron P.N.
      • et al.
      Avalanche victims in cardiac arrest are unlikely to survive despite adherence to medical guidelines.
      • Gasteiger L.
      • Putzer G.
      • Unterpertinger R.
      • et al.
      Solid Organ Donation From Brain-dead Donors With Cardiorespiratory Arrest After Snow Avalanche Burial: A Retrospective Single-center Study.

      Conclusions

      The initial management of victims in CA with a short (≤60 minutes) duration of burial should focus on ventilation. Initial management of victims with a long (>60 minutes) duration of burial should focus on a prolonged (1 minute) check for signs of life, including vital signs, and detection of hypothermia. Victims with a burial duration > 60 minutes, an obstructed airway, and asystole should not be resuscitated. Victims with a core temperature < 30 ˚C, as well as victims with an unknown core temperature but with a long (>60 minutes) duration of burial and witnessed CA or a CA rhythm of VF or PEA, should be transported with ongoing CPR to a hospital with ECLS capability.

      Conflict Of Interest

      None to declare. None of the authors has any financial or personal relationships that could have influenced the work.

      Acknowledgements

      We thank Duncan Gray for his help and input regarding the initial management and decision-making algorithms, Peter Mair for his critical review and feedback, especially on the in-hospital management of avalanche victims in CA, and Alexandre Kottmann, Peter Paal and Sven Christjar Skaiaa, for their help in translating information and extracting the data from articles in German and Norwegian. We are grateful for invaluable help and assistance in the literature review process by the team at the Lausanne University Medical Library, Lausanne, Switzerland. We also thank Stephanie Thomas, President of the ICAR Avalanche Rescue Commission, for organising the inclusion of members of the Avalanche Rescue Commission (CA, RM) in the project. We thank Olivier Hugli for creating the figure in Supplemental file 4.

      Funding Source

      This research received no external funding. The article processing charges were funded by the Lausanne University Open Access program.

      Appendix A. Supplementary data

      The following are the Supplementary data to this article:

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