Restoration and maintenance of end-organ oxygen delivery are fundamental goals of critical care medicine.
1.Measuring mixed or central venous oxygen saturation allows the adequacy of systemic oxygen delivery to be estimated. When oxygen delivery is insufficient to meet metabolic demand, the fraction of arterial oxygen extracted and utilized by tissue increases and venous oxygen saturation falls, eventually heralding cellular hypoxia, anaerobic metabolism, and organ damage. While systemic venous saturation monitoring has a biological rationale and face validity, randomized controlled trials have failed to demonstrate benefit to patient centered outcomes.
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Need for oxygen enrichment in myocardial infarction, shock and following cardiac arrest.
Acta Anaesthesiol Scand Suppl. 1968; 29: 127-145
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Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial.
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3.This may be explained in part by complexity identifying the correct underlying pathophysiologic cause(s) of abnormal values.
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Intensive Care Med. 2002; 28: 256-264
4.Thus, there remains great interest in pushing oxygen monitoring to the level of the end organs that drive clinical outcomes.
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6.Brain injury is the primary determinant of outcome in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA), and prevention of secondary brain injury may save lives and improve quality of recovery.
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7.Akin to systemic venous oxygen monitoring, it is possible that insight into the dynamics of cerebral oxygen delivery and consumption can be gained by sampling cerebral venous outflow at the jugular bulb.
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Cerebrovenous oxygen saturation monitoring: practical considerations and clinical relevance.
Intensive Care Med. 2000; 26: 1028-1036
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Published online: November 05, 2021
Accepted: October 29, 2021
Received: October 27, 2021
© 2021 Elsevier B.V. All rights reserved.
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- Elevated jugular venous oxygen saturation after cardiac arrestResuscitationVol. 169
- PreviewWe performed a retrospective analysis of our earlier study on cerebral oxygenation monitoring by jugular venous oximetry (SjvO2) in patients of out-of-hospital cardiac arrest (OHCA). The study was focused on high SjvO2 values (≥75%) and their association with neurological outcomes and serum neuron-specific enolase (NSE) concentration.