Abstract
Introduction
Neurological status following out-of-hospital cardiac arrest is commonly assessed
using measures such as the Cerebral Performance Category (CPC) at hospital discharge.
However, it remains unclear if these measures accurately reflect long-term neurological
status after discharge. The objective of this systematic review was to determine the
association between post-arrest neurological outcome scores at hospital discharge
and long-term (>6 months) neurological outcome scores.
Methods
Comprehensive database searches of Medline, Embase, and the Cochrane library databases
from inception to August 2019 were conducted and reference lists were hand-searched.
Randomized controlled trials (RCT) and prospective observational studies were included.
Results
After screening 7844 titles and abstracts independently and in duplicate, we included
7 studies with a total of 602 patients from 6 prospective observational studies and
1 RCT. Four studies reported long-term follow-up at 6 months post-arrest and three
studies reported follow-up at 1 year. In the studies with 6-month follow-up, 368 patients
(82.7%) had favorable short-term neurological scores (CPC 1–2) at discharge or 30
days post-arrest, and 352 patients (79.1%) had favorable scores at 6 months post-arrest.
In the studies with 1-year follow-up, 101 patients (64.3%) had favorable neurological
scores at discharge or 30 days post-arrest, and 91 patients (59.5%) patients had favorable
neurological scores at 1 year.
Conclusions
Long-term neurological outcome scores following OHCA were consistent with short-term
outcome at hospital discharge or 30 days post-arrest. All included studies measured
neurological outcome using CPC, further studies are needed using other standards to
better elucidate patient-centered long-term neurological outcome.
Keywords
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Article info
Publication history
Published online: April 15, 2020
Accepted:
April 6,
2020
Received in revised form:
March 10,
2020
Received:
December 11,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
