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One-year outcome of patients admitted after cardiac arrest compared to other causes of ICU admission. An ancillary analysis of the observational prospective and multicentric FROG-ICU study

  • Antoine Kimmoun
    Affiliations
    Medical Intensive Care Unit, Nancy University Hospital, University of Lorraine, Nancy, France

    UMR-S 942, INSERM, Paris, France

    U1116, INSERM, Nancy, France
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  • Alain Cariou
    Affiliations
    Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique—Hôpitaux de Paris, Paris Descartes University, Paris Cardiovascular Research Center-INSERM U970 (PARCC), Paris Sudden Death Expertise Center, Paris, France
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  • Etienne Gayat
    Affiliations
    Department of Anesthesiology, Critical Care and Burn Unit, Saint Louis—Lariboisière University Hospitals, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France
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  • Elodie Feliot
    Affiliations
    Department of Anesthesiology, Critical Care and Burn Unit, Saint Louis—Lariboisière University Hospitals, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France
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  • Koji Takagi
    Affiliations
    Department of Anesthesiology, Critical Care and Burn Unit, Saint Louis—Lariboisière University Hospitals, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France
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  • Bruno Megarbane
    Affiliations
    Medical Intensive Care Unit, Hôpitaux Universitaires Saint Louis—Lariboisière, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, INSERM UMRS-1144, Paris, France
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  • Alexandre Mebazaa
    Affiliations
    Department of Anesthesiology, Critical Care and Burn Unit, Saint Louis—Lariboisière University Hospitals, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France
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  • Nicolas Deye
    Correspondence
    Corresponding author.
    Affiliations
    Medical Intensive Care Unit, Hôpitaux Universitaires Saint Louis—Lariboisière, Assistance Publique—Hôpitaux de Paris, Université Paris Diderot—Paris 7, Sorbonne Paris Cité,UMR-S 942, INSERM, Paris, France
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  • FROG-ICU Study investigators

      Abstract

      Objective

      While cardiac arrest (CA) patients discharged alive from intensive care unit (ICU) are considered to have good one-year survival but potential neurological impairment, comparisons with other ICU sub-populations non-admitted for CA purpose are still lacking. This study aimed to compare long-term outcome and health-related quality of life (HRQOL) between CA patients and patients admitted to ICU for all other causes.

      Methods

      In 1635 patients discharged alive from 21 European ICUs in an ancillary analysis of a prospective multicentric cohort, we compared CA causes of ICU admission to all other causes of ICU admissions (named non-CAs). The primary endpoint was one-year survival rate after ICU discharge. Secondary endpoints included HRQOL at 3, 6 and 12 months after ICU discharge using the outcome survey short form‐36 (SF36). Propensity score matching was used to consider the probability of having CA.

      Results

      Of the 1635 patients, 1561 were included in this study comprised of 1447 non-CAs and 114 CAs. At one-year in the non-matched population, survival rate was greater in the CA group 89% versus the non-CA group 78% (log rank p = 0.0056). In the matched population, this difference persisted between CAs and non-CAs (log rank p = 0.049). The physical component summary of the SF36 scale was higher in the CA group than in the non-CA group at all time points in both non-matched and matched populations.

      Conclusions

      CA patients discharged alive from ICU have a better one-year survival and a better HRQOL specifically on physical functions than patients admitted to ICU for other causes.

      Trial registration

      ClinicalTrials.gov NCT01367093; registered on June 6, 2011.

      Keywords

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