Abstract
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus
on survival. A lack of consistency in outcome reporting between trials limits the
opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome
Set for Cardiac Arrest), a partnership between patients, their partners, clinicians,
research scientists, and the International Liaison Committee on Resuscitation, sought
to develop a consensus core outcome set for cardiac arrest for effectiveness trials.
Core outcome sets are primarily intended for large, randomised clinical effectiveness
trials (sometimes referred to as pragmatic trials or phase III/IV trials) rather than for pilot or efficacy studies. A systematic review of the literature
combined with qualitative interviews among cardiac arrest survivors was used to generate
a list of potential outcome domains. This list was prioritised through a Delphi process,
which involved clinicians, patients, and their relatives/partners. An international
advisory panel narrowed these down to 3 core domains by debate that led to consensus.
The writing group refined recommendations for when these outcomes should be measured
and further characterised relevant measurement tools. Consensus emerged that a core
outcome set for reporting on effectiveness studies of cardiac arrest (COSCA) in adults
should include survival, neurological function, and health-related quality of life.
This should be reported as survival status and modified Rankin scale score at hospital
discharge, at 30 days, or both. Health-related quality of life should be measured
with ≥1 tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey,
and EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac
arrest, if resources allow. © 2018 European Resuscitation Council and American Heart
Association, Inc. Published by Elsevier B.V. All rights reserved.
Keywords
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Article info
Publication history
Published online: April 26, 2018
Footnotes
☆This article has been copublished in Circulation: Cardiovascular Quality and Outcomes.
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© 2018 European Resuscitation Council and American Heart Association, Inc. Published by Elsevier B.V. All rights reserved.
