Poor neurologic outcomes in children after a neurologic insult from hypoxic ischemic
injury (HII) continues to be an important and challenging issue. It is not clear what
interventions can be done after the injury to improve long-term neurologic outcomes.
In the Therapeutic Hypothermia after Pediatric Cardiac Arrest Trials, both the in-hospital
and out-of-hospital cardiac arrest groups demonstrated no benefit of survival with
a favorable neurobehavorial outcome with the use of therapeutic hypothermia [
[1]
,
[2]
]. In the out-of-hospital arrest cohort, only 16% of patients with baseline good neurologic
function were alive with good neurologic outcome 1-year after the cardiac arrest [
[2]
]. Consequently, it is critically important to develop interventions that can reduce
the burden of neurologic injury in children after HII.To read this article in full you will need to make a payment
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References
- Therapeutic hypothermia after in-hospital cardiac arrest in children.N Engl J Med. 2017; 376: 318-329
- Therapeutic hypothermia after out-of-hospital cardiac arrest in children.N Engl J Med. 2015; 372: 1898-1908
- Cerebral blood flow velocity and autoregulation in pediatric patients following a global hypoxic ischemic insult.Resuscitation. 2018; 126: 191-196
- Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children.Resuscitation. 2012; 83: 1456-1461
- Part 12: pediatric advanced life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care.Circulation. 2015; 132: S526-42
- An observational near-infrared spectroscopy study on cerebral autoregulation in post-cardiac arrest patients: time to drop ‘one-size-fits-all' hemodynamic targets?.Resuscitation. 2015; 90: 121-126
- Are changes in cerebrovascular autoregulation following cardiac arrest associated with neurological outcome? Results of a pilot study.Resuscitation. 2015; 96: 192-198
- Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest.Stroke. 2001; 32: 128-132
- A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest.Resuscitation. 2014; 85: 1387-1393
- Early electroencephalographic background features predict outcomes in children resuscitated from cardiac arrest.Pediatr Crit Care Med. 2016; 17: 547-557
- Electroencephalogram monitoring in critically ill children: indications and strategies.Pediatr Neurol. 2012; 46: 158-161
Article info
Publication history
Published online: March 07, 2018
Accepted:
March 2,
2018
Received:
February 28,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
