Abstract
Aim
We explored the associations between global brain volumes, hippocampal subfield volumes
and verbal memory performance in long-term survivors of out-of-hospital cardiac arrest
(OHCA).
Methods
Three months after OHCA, survivors and healthy, age-matched controls were assessed
with cerebral MRI and the California Verbal Learning Test-II (CVLT-II). Volumetric
brain segmentation was performed automatically by FreeSurfer.
Results
Twenty-six OHCA survivors who were living independently in regular homes at the time
of assessment and 19 controls participated in the study. Thirteen of the survivors
had been conscious upon arrival to the emergency department. The other 13 survivors
had 0.5–7 days of inpatient coma before recovery. Memory was poorer in the OHCA group
that had been comatose beyond initial hospital admission compared to both other groups.
Total cortical volumes, total hippocampus volumes and several hippocampal subfield
volumes were significantly smaller in the OHCA group comatose beyond initial hospital
admission compared to controls. No significant differences between the OHCA group
conscious upon emergency department arrival and the other two groups were found for
brain volumes. No significant differences were observed between any groups for white
matter or total subcortical volumes. In OHCA survivors with recovery from inpatient
coma, the various CVLT-II trials were significantly, but differentially, correlated
to total gray matter volume, cortical volume and the hippocampal subfield subiculum.
Conclusion
In this small, single-site study, both hippocampal volume and cortical volume were
smaller in good outcome OHCA survivors 3 months after resuscitation in comparison
to healthy controls. Smaller cerebral volumes were correlated with poorer memory performance
Keywords
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Article info
Publication history
Published online: February 17, 2018
Accepted:
February 13,
2018
Received in revised form:
February 7,
2018
Received:
October 11,
2017
Footnotes
☆A Spanish translated version of the abstract of this article appears as Appendix in the final online version at https://doi.org/10.1016/j.resuscitation.2018.02.011.
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
