James Blundell: the first transfusion of human blood

  • Thomas F. Baskett
    Tel.: +1-902-470-6788; fax: +1-902-428-8640
    Department of Obstetrics and Gynaecology, Dalhousie University, 5980 University Avenue, Room 6039, Halifax, Nova Scotia, Canada B3J 3G9
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      In August, 1825, James Blundell, obstetrician and physiologist of Guy's Hospital, was summoned by a surgeon colleague, Mr Waller, to a woman dying from postpartum haemorrhage in the Finsbury Square district of London. The case was recorded by Mr Waller and was the first successful human blood transfusion [
      • Waller C.
      Case of uterine hemorrhage, in which the operation of transfusion was successfully performed.
      ].The vein in the bend of the arm was laid bare, and an incision of sufficient extent to admit the pipe of the syringe was made into it…. The syringe used by Dr B. was similar to the common injecting syringe, and contained two ounces…. The blood was drawn from the patient's husband into a tumbler, and Dr B. stood ready with his syringe to absorb it instantly, in fact, while it was flowing: it was then immediately introduced into the orifice in the vein, and cautiously injected. No effect appeared to be produced by the first injection of two ounces, but towards the end of the second there was an approach to syncope; the pulse fell a little; there was sighing… [
      • Waller C.
      Case of uterine hemorrhage, in which the operation of transfusion was successfully performed.
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        • Waller C.
        Case of uterine hemorrhage, in which the operation of transfusion was successfully performed.
        Med. Phys. J. 1825; 54: 273-277
        • Blundell J.
        Experiments on the transfusion of blood by the syringe.
        Med. Chir. Trans. 1818; 9: 56-92
        • Blundell J.
        Lectures on the theory and practice of midwifery. Delivered at Guy's hospital by Dr James Blundell. Lecture 28: After-management of floodings, and on transfusion.
        Lancet. 1827; 8: 673-681
        • Wren C.
        An account of the rise and attempts of a way to conveigh liquors immediately into the mass of blood.
        Phil. Trans. 1665; 1: 128-130
        • Lower R.
        The method observed in transfusing the blood out of one live animal into another.
        Phil. Trans. 1665; 1: 353-357
        • Boulton T.B.
        Classical file: James Blundell, MD, FRCP, and the introduction of the transfusion of human blood to man.
        Surv. Anesthesiol. 1986; 30: 100-106
        • Blundell J.
        The principles and practice of obstetricy. E. Cox, London1834: 247, 337, 580, 838
        • Blundell J.
        Observations on transfusion of blood by Dr Blundell. With a description of his gravitator.
        Lancet. 1828; 2: 321-324
        • Blundell J.
        Some account of a case of obstinate vomiting in which an attempt was made to prolong life by the injection of blood into the veins.
        Med. Chir. Trans. 1818; 10: 310-312
        • Jones H.W.
        • Mackmull G.
        The influence of James Blundell on the development of blood transfusion.
        Ann. Med. Hist. 1928; 10: 242-248
        • Doubleday E.
        Case of uterine hemorrhage successfully treated by the operation of transfusion.
        Med. Phys. J. 1825; 54: 380-386
      1. Medical Society of London Report. November 14, 1825. Lancet 1825;9: 295.

        • Blundell J.
        Successful case of transfusion.
        Lancet. 1829; 1: 431-432
        • Hicks J.B.
        Cases of transfusion with some remarks on a new method of performing the operation.
        Guy's Hosp. Rep. 1869; 14: 1-14
        • Aveling J.H.
        Immediate transfusion in England: seven cases, and the author's method of operating.
        Obstet. J. Gr. Brit. Irel. 1873; 5: 289-311
        • Blundell J.
        Lancet. 1878; 1 (Obituary): 255-256
        • Baskett T.F.
        On the Shoulders of Giants: Eponyms and Names in Obstetrics and Gynaecology. RCOG Press, London1996: 22-23
        • Blundell J.
        BMJ. 1878; 1 (Obituary): 351-352