Abstract
Aim
To describe cognitive functioning with neuropsychological tests and examine predictors
of cognitive outcome in adult survivors of out-of-hospital cardiac arrest (OHCA) of
cardiac cause.
Method
The study was prospective and took place at the University hospital of North-Norway.
Only patients eligible of neuropsychological assessment three months after OHCA were
asked to participate. Cognitive test performance was compared to large samples of
age-corrected normative data. General linear models were used to determine predictors
of a cognitive composite score and performance on separate cognitive tests. The predictors
assessed were coma duration, hypothermia treatment and time to restoration of spontaneous
circulation. We aimed to control for demographic variables, medical comorbidity and
affective symptoms.
Results
45 survivors (4 women) completed the assessment. Neuropsychological tests of fine
motor functioning, memory, attention and executive functions were significantly below
normative means. Depending on the test, impairment ranged from 9 to 31%. For twenty-five
survivors (56%), all cognitive tests were within the normal range. Shorter coma duration
and induced hypothermia treatment were associated with favourable cognitive outcomes
and explained 45% of the variability in the cognitive composite score. Coma duration
was predictive across all cognitive tests, hypothermia treatment of specific tests
of memory, attention and executive functioning.
Conclusions
Cognitive outcome was normal in more than half of the survivors. Shorter coma duration
and induced hypothermia were associated with favourable cognitive outcomes in the
participating survivors three months after OHCA.
Institutional protocol number: 2009/1395.
Keywords
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Article info
Publication history
Published online: August 30, 2014
Accepted:
August 8,
2014
Received in revised form:
August 7,
2014
Received:
April 8,
2014
Footnotes
☆A Spanish translated version of the summary of this article appears as Appendix in the final online version at http://dx.doi.org/10.1016/j.resuscitation.2014.08.010.
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
