Resuscitation
Volume 36, Issue 3 , Pages 175-180 , March 1998

Effects of lidocaine and mexiletine on defibrillation energy requirements in animals treated with flecainide

  • Shigehito Sato

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81 298 533102; fax: +81 298 533102.
    • ,
  • Naoya Imagawa

      Affiliations

    • Student in the Master's Program in Medical Sciences, University of Tsukuba.

Received 1 September 1997 ,Revised 25 January 1998 ,Accepted 25 January 1998.

References 

  1. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al  Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the cardiac arrhythmia suppression trial. New Engl J Med. 1991;324:781–788
  2. Jung W, Manz M, Pizzulli L, Pfeiffer D, Luderitz B. Effects of chronic amiodarone therapy on defibrillation threshold. Am J Cardiol. 1992;70:1023–1027
  3. Fain ES, Dorian P, Davy JM, Kates RE, Winkle RA. Effects of encainide and its metabolises on energy requirements for defibrillation. Circulation. 1986;73:1334–1341
  4. Wehr M, Noll B, Krappe J. Flecainide induced aggravation of ventricular arrhythmias. Am J Cardiol. 1985;55:1643–1644
  5. Dorian P, Fain ES, Davy JM. Lidocaine causes a reversible, concentration dependent increase in defibrillation energy requirements. J Am Coll Cardiol. 1986;8:327–332
  6. Marinchak RA, Friehling TD, Kline RA, Stohler J, Kowery PR. Effect of antiarrythmic drugs on defibrillation threshold: case report of an adverse effect of mexiletine and review of the literature. PACE. 1988;11:7–12
  7. Hernandez R, Mann DE, Breckinridge S, Williams GR, Reiter MJ. Effects of flecainide on defibrillation thresholds in the anesthetized dog. J Am Coll Cardiol. 1989;14:777–781
  8. Brugada J, Boersma L, Kirchhof C, Allessie M. Proarrhythmic effects of flecainide. Circulation. 1991;84:1808–1818
  9. Sato S, Tsuji MH, Naito H. Mexiletine has no effect on defibrillation energy requirements in dogs. Pacing Clin Electrophysiol. 1994;17:2279–2284
  10. Benet LZ, Williams RL. Pharmacokinetic data. In: Gilman AG, Rall TW, Nies AS, Taylor P, editors. The Pharmacological Basis of Therapeutics. 8th ed. Oxford: Pergamon Press, 1990: 1688–92.
  11. Murakawa Y, Toda I, Nozaki A, Kawakubo K, Sugimoto T. Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold. Cardiology. 1989;76:58–66
  12. Usui M, Inoue H, Saihara S, Sugimoto T. Antifibrillatory effects of Class III antiarrhythmic drugs: comparative study with flecainide. J Cardiovasc Pharmacol. 1993;21:376–383
  13. Euler DE, Scanlon PJ. Comparative effects of antiarrhythmic drugs on the ventricular fibrillation threshold. J Cardiovasc Pharmacol. 1988;11:291–298
  14. Hernandez R, Mann DE, Breckinridge S, Williams GR, Reiter MJ. Effects of flecainide on defibrillation thresholds in the anesthetized dog. J Am Coll Cardiol. 1989;14:777–781
  15. Ujhelyi MR, O'Rangers EA, Kluger J, Fan C, Chow M. Defibrillation energy requirements during moricizine and moricizine-lidocaine therapy. J Cardiovasc Pharmacol. 1992;20:932–939
  16. Kerber RE, Pandian NG, Jensen SR, Constantine L, Kieso RA, Melton J, et al. Effect of lidocaine and bretylium on energy requirements for transthoracic defibrillation: experimental studies. J Am Coll Cardiol. 1986;7:397–405
  17. Jones DL, Klein GJ, Guiraudon GM, et al.  Effects of lidocaine and verapamil on defibrillation in humans. J Electrocardiol. 1991;24:299–305
  18. Babbs CF, Yim GKW, Whistler SJ, Tacker WA, Geddes LA. Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs. Am Heart J. 1979;98:345–350
  19. Ujhelyi MR, Schur M, Frede T, Markel ML. Differential effects of lidocaine on defibrillation threshold with monophasic versus biphasic shock waveforms. Circulation. 1995;92:1644–1650
  20. Echt DS, Gremillion ST, Lee JT, Roden DM, Murray KT, Borganelli M, et al. Effects of procainamide and lidocaine on defibrillation energy requirements in patients receiving implantable cardioverter defibrillation devices. J Cardiovasc Electrophysiol. 1994;5:752–760
  21. Ruffy R, Schechtman K, Monje E, Sandza J. Adrenergically mediated variations in the energy required to defibrillate the heart: observations in closed-chest, nonanesthetized dogs. Circulation. 1986;73:374–380
  22. Babbs CF, Whistler SJ, Yim GK, Tacker WA, De Garanvilla B. Dependence of defibrillation threshold upon extracellular/intracellular K+ concentrations. J Electrocardiol. 1980;13:73–78
  23. Grant AO, Trantham JL, Brown KK, Strauss HC. pH dependent effects of quinidine on the kinetics of dV/dt-max. Circ Res. 1982;50:210–217
  24. Babbs CF. Effect of pentobarbital anesthesia on ventricular defibrillation threshold in dogs. Am Heart J. 1978;95:331–337

PII: S0300-9572(98)00024-0

Resuscitation
Volume 36, Issue 3 , Pages 175-180 , March 1998

Article Tools

* Image Usage & Resolution