Resuscitation
Volume 81, Issue 4 , Pages 393-397 , April 2010

Induced hypothermia and determination of neurological outcome after CPR in ICUs in the Netherlands: Results of a survey

  • Aline Bouwes

      Affiliations

    • Department of Intensive Care, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands
    • Department of Neurology, Sint Lucas Andreas Hospital, P.O. Box 9243, 1006 AE, Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of Intensive Care, Room C3-423, Academic Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. Tel.: +31 20 5662509; fax: +31 20 5669568.
  • ,
  • Michael A. Kuiper

      Affiliations

    • Department of Intensive Care, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands
    • Department of Intensive Care, Medical Center Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, The Netherlands
  • ,
  • Albert Hijdra

      Affiliations

    • Department of Neurology, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands
  • ,
  • Janneke Horn

      Affiliations

    • Department of Intensive Care, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands

Received 21 July 2009 ,Revised 19 November 2009 ,Accepted 30 December 2009.

References 

  1. Benson DW, Williams GR, Spencer FC, Yates AJ. The use of hypothermia after cardiac arrest. Anesth Analg. 1959;38:423–428
  2. Bernard SA, Gray TW, Buist MD. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563
  3. The Hypothermia after Cardiac Arrest (HACA) Study Group . Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest: the hypothermia after cardiac arrest study group. N Engl J Med. 2002;346:549–556
  4. International Liaison Committee on Resuscitation . International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation. 2005;112:III-1–III-136
  5. American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005;112:IV-1–IV-203
  6. Merchant RM, Soar J, Skrifvars MB, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med. 2006;34:1935–1940
  7. Sander M, Heymann C, Spies C. Implementing the International Liaison Committee on Resuscitation guidelines on hypothermia after cardiac arrest: still a long way to go?. Crit Care. 2006;10:407
  8. Wolfrum S, Radke PW, Pischon T, Willich SN, Schunkert H, Kurowski V. Mild therapeutic hypothermia after cardiac arrest: a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units. Resuscitation. 2007;72:207–213
  9. Laver SR, Padkin A, Atalla A, Nolan JP. Therapeutic hypothermia after cardiac arrest: a survey of practice in intensive care units in the United Kingdom. Anaesthesia. 2006;61:873–877
  10. Kennedy J, Green RS, Stenstrom R. The use of induced hypothermia after cardiac arrest: a survey of Canadian emergency physicians. CJEM. 2008;10:125–130
  11. Wijdicks EFM, Hijdra A, Young GB, Bassetti CL, Wiebe S. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the quality standards subcommittee of the American academy of neurology. Neurology. 2006;67:203–210
  12. Busch M, Søreide E. Prognostication after out-of-hospital cardiac arrest, a clinical survey. Scand J Trauma Resusc Emerg Med. 2008;16:9
  13. Oksanen T, Pettila V, Hynynen M, Varpula T. Therapeutic hypothermia after cardiac arrest: implementation and outcome in Finnish intensive care units. Acta Anaesthesiol Scand. 2007;51:866–871
  14. Majersik JJ, Silbergleit R, Meurer WJ, Brown DL, Lisabeth LD, Morgenstern LB. Public health impact of full implementation of therapeutic hypothermia after cardiac arrest. Resuscitation. 2008;77:189–194
  15. Tiainen M, Kovala TT, Takkunen OS, Roine RO. Somatosensory and brainstem auditory evoked potentials in cardiac arrest patients treated with hypothermia. Crit Care Med. 2005;33:1736–1740
  16. Bouwes A, Binnekade JM, Zandstra DF, et al. Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation. Neurology. 2009;73:1457–1461
  17. Koht A, Schütz W, Schmidt G, Schramm J, Watanabe E. Effects of etomidate, midazolam, and thiopental on median nerve somatosensory evoked potentials and the additive effects of fentanyl and nitrous oxide. Anesth Analg. 1988;67:435–441
  18. Sloan TB, Fugina ML, Toleikis JR. Effects of midazolam on median nerve somatosensory evoked potentials. Br J Anaesth. 1990;64:590–593
  19. Tortorici MA, Kochanek PM, Poloyac SM. Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med. 2007;35:2196–2204
  20. Al Thenayan E, Savard M, Sharpe M, Norton L, Young B. Predictors of poor neurologic outcome after induced mild hypothermia following cardiac arrest. Neurology. 2008;71:1535–1537
  21. Rossetti AO, Oddo M, Liaudet L, Kaplan PW. Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology. 2009;72:744–749
  22. Hovland A, Nielsen EW, Klüver J, Salvesen R. EEG should be performed during induced hypothermia. Resuscitation. 2006;68:143–146
  23. Sunde K, Dunlop O, Rostrup M, Sandberd M, Sjøholm H, Jacobsen D. Determination of prognosis after cardiac arrest may be more difficult after introduction of therapeutic hypothermia. Resuscitation. 2006;69:29–32
  24. Morris HR, Howard RS, Brown P. Early myoclonic status and outcome after cardiorespiratory arrest. J Neurol Neurosurg Psychiatry. 1998;64:267–268
  25. English WA, Giffin NJ, Nolan JP. Myoclonus after cardiac arrest: pitfalls in diagnosis and prognosis. Anaesthesia. 2009;64:908–911
  26. Datta S, Hart GK, Opdam H, Gutteridge G, Archer J. Post-hypoxic myoclonic status: the prognosis is not always hopeless. Crit Care Resusc. 2009;11:39–41

 A Spanish translated version of the abstract of this article appears as Appendix in the final online version at doi:10.1016/j.resuscitation.2009.12.032.

PII: S0300-9572(10)00019-5

doi: 10.1016/j.resuscitation.2009.12.032

Resuscitation
Volume 81, Issue 4 , Pages 393-397 , April 2010