Resuscitation
Volume 81, Issue 3 , Pages 353-358 , March 2010

Perfluorocarbon induced intra-arrest hypothermia does not improve survival in a swine model of asphyxial cardiac arrest

Received 6 March 2009 ,Revised 30 November 2009 ,Accepted 30 November 2009.

References 

  1. Nadkarni VM, Larkin GL, Peberdy MA, et al. National Registry of Cardiopulmonary Resuscitation Investigators. First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA. 2006;295:96–98
  2. The Hypothermia after Cardiac Arrest Study Group . Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–556
  3. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563
  4. Nolan JP, Morley PT, VandenHoek TL, Hickey RW. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the international liaison committee on resuscitation. Circulation. 2003;108:118–121
  5. Boddicker KA, Zhang Y, Zimmerman MB, Davies LR, Kerber RE. Hypothermia improves defibrillation success and resuscitation outcomes from ventricular fibrillation. Circulation. 2005;111:3195–3201
  6. Staffey KS, Dendi R, Brooks LA, et al. Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model. Resuscitation. 2008;78:77–84
  7. Menegazzi JJ, Rittenberger JC, Suffoletto BP, et al. Effects of pre-arrest and intra-arrest hypothermia on ventricular fibrillation and resuscitation. Resuscitation. 2009;80:126–132
  8. Riter HR, Brooks LA, Pretorius AM, Ackermann LW, Kerber RE. Intra-arrest hypothermia: both cold liquid ventilation with perfluorocarbons and cold intravenous saline rapidly achieve hypothermia, but only cold liquid ventilation improves resumption of spontaneous circulation. Resuscitation. 2009;80:561–566
  9. Adams JA, Bassuk JA, Arias J, et al. Periodic acceleration (pGz) CPR in a swine model of asphyxia induced cardiac arrest. Short-term hemodynamic comparisons. Resuscitation. 2008;77:132–138
  10. Lottes AE, Rundell AE, Geddes LA, Kemeny AE, Otlewski MP, Babbs CF. Sustained abdominal compression during CPR raises coronary perfusion pressures as much as vasopressor drugs. Resuscitation. 2007;75:515–524
  11. Idris AH, Becker LB, Ornato JP, et al. Utstein-style guidelines for uniform reporting of laboratory CPR research. A statement for healthcare professionals from a Task Force of the American Heart Association, the American College of Emergency Physicians, the American College of Cardiology. Resuscitation. 1996;33:69–84
  12. DeBehnke DJ, Hilander SJ, Dobler DW, Wickman LL, Swart GL. The hemodynamic and arterial blood gas response to asphyxiation: a canine model of pulseless electrical activity. Resuscitation. 1995;30:169–175
  13. Berg RA, Henry C, Otto CW, et al. Initial end-tidal CO2 is markedly elevated during cardiopulmonary resuscitation after asphyxial cardiac arrest. Pediatr Emerg Care. 1996;12:245–248
  14. Morimoto Y, Kemmotsu O, Morimoto Y. Extramyocardial acidosis impairs cardiac resuscitability in isolated, perfused, rat hearts. Crit Care Med. 1996;24:1719–1723
  15. Mosca SM, Escudero E, Gelpi RJ, Kosoglov AT, Rinaldi GJ, Cingolani HE. Myocardial flow distribution. II. Empty beating heart, ventricular fibrillation and cardiac arrest. Arch Int Physiol Biochim. 1981;89:357–364
  16. Xiao F, Safar P, Radovsky A. Mild protective and resuscitative hypothermia for asphyxial cardiac arrest in rats. Am J Emerg Med. 1998;16:17–25
  17. Agnew DM, Koehler RC, Guerguerian AM, et al. Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatr Res. 2003;52:253–262
  18. Hicks SD, DeFranco DB, Callaway CW. Hypothermia during reperfusion after asphyxial cardiac arrest improves functional recovery and selectively alters stress-induced protein expression. J Cereb Blood Flow Metab. 2000;20:520–530
  19. Bartels M, Tjan DH, Reussen EM, van Zanten AR. Therapeutic hypothermia after prolonged cardiopulmonary resuscitation for pulseless electrical activity. Neth J Med. 2007;65:38–41
  20. Abella BS, Zhao D, Alvarado J, Hamann K, Vanden Hoek TL, Becker LB. Intra-arrest cooling improves outcomes in a murine cardiac arrest model. Circulation. 2004;109:2786–2791
  21. Zhao D, Abella BS, Beiser DG, et al. Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest. Resuscitation. 2008;77:242–249
  22. Shao ZH, Chang WT, Chan KC, et al. Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling. Am J Physiol Heart Circ Physiol. 2007;292:H1995–H2003
  23. Berg RA, Hilwig RW, Kern KB, Ewy GA. ‘Bystander’ chest compressions and assisted ventilation independently improve outcome from piglet asphyxial pulseless ‘cardiac arrest’. Circulation. 2000;101:1743–1748
  24. Berg RA, Hilwig RW, Kern KB, Babar I, Ewy GA. Simulated mouth-to-mouth ventilation and chest compressions (bystander cardiopulmonary resuscitation) improves outcome in a swine model of prehospital pediatric asphyxial cardiac arrest. Crit Care Med. 1999;27:1893–1899
  25. Bobrow BJ, Zuercher M, Ewy GA, et al. Gasping during cardiac arrest in humans is frequent and associated with improved survival. Circulation. 2008;118:2550–2554
  26. Berg RA, Kern KB, Otto CW, Samson RA, Sanders AB, Ewy GA. Ventricular fibrillation in a swine model of acute pediatric asphyxial cardiac arrest. Resuscitation. 1996;33:147–153
  27. Hallstrom A, Rea TD, Mosesso VN, et al. The relationship between shocks and survival in out-of-hospital cardiac arrest patients initially found in PEA or asystole. Resuscitation. 2007;74:418–426
  28. Kim F, Olsufka M, Maynard C, et al. Pilot randomized clinical trial of pre-hospital induction of mild hypothermia in out-of-hospital cardiac arrest in patients with a rapid infusion of 4°C normal saline. Circulation. 2007;115:3064–3070
  29. Menegazzi J, Rittenberger JC, Suffoletto B, et al. Effects of pre-arrest and intra-arrest hypothermia on ventricular fibrillation and resuscitation. Resuscitation. 2009;80:126–132
  30. American Heart Association Guidelines for CPR and Emergency Cardiac Care. Circulation 2005;112:IV-47–50.

☆ A Spanish translated version of the abstract of this article appears as Appendix in the final online version at doi:10.1016/j.resuscitation.2009.11.018.

PII: S0300-9572(09)00621-2

doi: 10.1016/j.resuscitation.2009.11.018

Resuscitation
Volume 81, Issue 3 , Pages 353-358 , March 2010

Article Tools

* Image Usage & Resolution