Resuscitation
Volume 80, Issue 5 , Pages 561-566 , May 2009

Intra-arrest hypothermia: Both cold liquid ventilation with perfluorocarbons and cold intravenous saline rapidly achieve hypothermia, but only cold liquid ventilation improves resumption of spontaneous circulation

Received 10 July 2008 ,Revised 3 December 2008 ,Accepted 21 January 2009.

References 

  1. Nolan JP, Morley PT, Vanden Hoek TL, et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Circulation. 2003;108:118–121
  2. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2005; 112:IV-1–IV-5.
  3. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563
  4. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–556
  5. Staffey KS, Dendi R, Brooks LA, et al. Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model. Resuscitation. 2008;78:77–84
  6. Wolfson MR, Shaffer TH. Liquid ventilation: an adjunct for respiratory management. Ped Anesthesia. 2004;14:15–23
  7. Steinhorn DM, Papo MC, Rotta AT, et al. Liquid ventilation attenuates pulmonary oxidative damage. J Crit Care. 1999;14:20–28
  8. Hirschl RB, Pranikoff T, Wise C, et al. Initial experience with partial liquid ventilation in adult patients with the acute respiratory distress syndrome. JAMA. 1996;275:383–389
  9. Leach CL, Greenspan JS, Rubenstein SD, et al. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. N Engl J Med. 1996;335:761–767
  10. Jiang L, Wang Q, Liu Y, et al. Total liquid ventilation reduces lung injury in piglets after cardiopulmonary bypass. Ann Thor Surg. 2006;82:124–130
  11. Ko AC, Hirsh E, Wong A, et al. Segmental hemodynamics during partial liquid ventilation in isolated rat lungs. Resuscitation. 2003;57:85–91
  12. Bernard S, Buist M, Monteiro O, Smith K, et al. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation. 2003;56:9–13
  13. Kämäräinen A, Virkkunen I, Tenhunen J, Yli-Hankala A, Silfvast T. Prehospital induction of therapeutic hypothermia during CPR: a pilot study. Resuscitation. 2008;76:360–363
  14. Nordmark J, Rubertsson S. Induction of mild hypothermia with infusion of cold (4°C) fluid during ongoing experimental CPR. Resuscitation. 2005;66:357–365
  15. Kim F, Olsufka M, Carlbom C, et al. Pilot study of rapid infusion of 2L of 4°C normal saline for induction of hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest. Circulation. 2005;112:715–719
  16. Nozari A, Safar P, Stezoski W, et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation. 2006;113:2690–2696
  17. Kim F, Olsufka M, Longstreth WT, et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4°C normal saline. Circulation. 2007;115:3064–3070
  18. Lottes AE, Rundell AE, Geddes LA, Kemeny AE, Otlewski MP, Babbs CF. Sustained abdominal compression during CPR raises coronary perfusion pressure as much as vasopressor drugs. Resuscitation. 2007;75:515–524
  19. Boddicker K, Zhang Y, Davies R, Kerber RE. Hypothermia improves defibrillation success and resuscitation outcomes from ventricular fibrillation. Circulation. 2005;111:3195–3201
  20. Ditchey RV, Lindenfeld J. Potential adverse effects of volume loading on perfusion of vital organs during closed-chest resuscitation. Circulation. 1984;69:181–189
  21. Yannopoulos D, Zviman M, Kolandaivelu R, et al. Intra-CPR hypothermia with and without volume loading in an ischemic model of cardiac arrest. Circulation. 2008;118(Suppl. 2):S1448;[Abstract]
  22. Tissier R, Hamanaka K, Kuno A, Parker JC, Cohen MV, Downey JM. Total liquid ventilation provides ultra-fast cardioprotective cooling. J Am Coll Cardiol. 2007;49:601–605
  23. Otake H, Shite J, Paredes OL, et al. Catheter-based transcoronary myocardial hypothermia attenuates arrhythmia and myocardial necrosis in pigs with acute myocardial infarction. J Am Coll Cardiol. 2007;49:250–260
  24. Brain JD, Molina RM, DeCamp MM, Warner AE. Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species. Am J Physiol. 1999;276:L146–154
  25. Winkler GC. Review of the significance of pulmonary intravascular macrophages with respect to animal species and age. Exp Cell Biol. 1989;57:281–286
  26. Yang SS, Jeng MJ, McShane R, Chen CY, Wolfson MR, Shaffer TH. Cold perfluorochemical-induced hypothermia protects lung integrity in normal rabbits. Biol Neonate. 2005;87:60–65

☆ A Spanish translated version of the summary of this article appears as Appendix in the final online version at doi:10.1016/j.resuscitation.2009.01.016.

PII: S0300-9572(09)00055-0

doi: 10.1016/j.resuscitation.2009.01.016

Resuscitation
Volume 80, Issue 5 , Pages 561-566 , May 2009

Article Tools

* Image Usage & Resolution