Resuscitation
Volume 73, Issue 1 , Pages 46-53 , April 2007

Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest

  • Andreas Kliegel

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Andreas Janata

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Cosima Wandaller

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Thomas Uray

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Alexander Spiel

      Affiliations

    • Department of Clinical Pharmacology, Medical University, Vienna, Austria
    • ,
  • Heidrun Losert

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Matthias Kliegel

      Affiliations

    • Department of Psychology, University of Zurich, Zurich, Switzerland
    • ,
  • Michael Holzer

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Moritz Haugk

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • ,
  • Fritz Sterz

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40400 1964/1952; fax: +43 1 40400 1965.
    • ,
  • Anton N. Laggner

      Affiliations

    • Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, Austria

Received 13 July 2006 ,Revised 17 August 2006 ,Accepted 29 August 2006.

References 

  1. Bernard SA, Gray TW, Buist MD, Jones BM, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563
  2. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–556
  3. Holzer M, Bernard SA, Hachimi-Idrissi S, et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med. 2005;33:414–418
  4. Nolan JP, Deakin CD, Soar J, Böttiger BW, Smith G. European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. Resuscitation. 2005;67(Suppl. 1):S39–S86
  5. Sterz F, Safar P, Tisherman S, Radovsky A, et al. Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs. Crit Care Med. 1991;19:379–389
  6. Markarian GZ, Lee JH, Stein DJ, Hong SC. Mild hypothermia: therapeutic window after experimental cerebral ischemia. Neurosurgery. 1996;38:542–551
  7. Holzer M, Müllner M, Sterz , et al. Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and bayesian approach stroke. 2006;37:1792–1797
  8. Al-Senani FM, Graffagnino C, Grotta JC, et al. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the coolgard system and icy catheter following cardiac arrest. Resuscitation. 2004;62:143–150
  9. Bernard S, Buist M, Monteiro O, Smith K. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation. 2003;56:9–13
  10. Virkkunen I, Yli-Hankala A, Silfvast T. Induction of therapeutic hypothermia after cardiac arrest in prehospital patients using ice-cold Ringer's solution: a pilot study. Resuscitation. 2004;62:299–302
  11. Kliegel A, Losert H, Sterz F, et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest-a feasibility study. Resuscitation. 2005;64:347–351
  12. Polderman K, Rijnsburger E, Peerdeman S, Girbes A. Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluid. Crit Care Med. 2005;33:2744–2751
  13. Kim F, Olsufka M, Carlbom D, et al. Pilot study of rapid infusion of 2L of 4°C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest. Circulation. 2005;112:715–719
  14. Jacobs I, Nadkarni V The ILCOR Task Force on Cardiac Arrest and Cardiopulmonary Resuscitation Outcomes. Cardiac arrest and cardiopulmonary resuscitation outcome reports update and simplification of the Utstein templates for resuscitation registries. A statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation. Resuscitation. 2004;63:233–249
  15. de Latorre F, Nolan J, Robertson C, Chamberlain D, Baskett P. European Resuscitation Council Guidelines 2000 for Adult Advanced Life Support—a statement from the Advanced Life Support Working Group 1 and approved by the Executive Committee of the European Resuscitation Council. Resuscitation. 2001;48:211–221
  16. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the ‘Utstein style’. Prepared by a Task Force of Representatives from the European Resuscitation Council, American Heart Association, Heart and Stroke Foundation of Canada, Australian Resuscitation Council. Resuscitation 1991; 22:1–26.

☆ A Spanish translated version of the summary of this article appears as Appendix in the final online version at 10.1016/j.resuscitation.2006.08.023.

PII: S0300-9572(06)00595-8

doi: 10.1016/j.resuscitation.2006.08.023

Resuscitation
Volume 73, Issue 1 , Pages 46-53 , April 2007

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