Resuscitation
Volume 66, Issue 2 , Pages 231-235 , August 2005

Excessive methaemoglobinaemia and multi-organ failure following 4-DMAP antidote therapy

  • Heinz Kerger

      Affiliations

    • Clinic for Anesthesiology and Critical Care Medicine, Evangelical Diakony Hospital, Wirthstr. 11, D-79110 Freiburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 761 1301 221; fax: +49 761 1301 621.
    • ,
  • Petroula Dodidou

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Faculty for Clinical Medicine of the Heidelberg University, Mannheim, Germany
    • ,
  • Daniela Passani-Kruppa

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Faculty for Clinical Medicine of the Heidelberg University, Mannheim, Germany
    • ,
  • Joachim Grüttner

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Faculty for Clinical Medicine of the Heidelberg University, Mannheim, Germany
    • ,
  • Monika Birmelin

      Affiliations

    • Clinic for Anesthesiology and Critical Care Medicine, Evangelical Diakony Hospital, Wirthstr. 11, D-79110 Freiburg, Germany
    • ,
  • Alexander Volz

      Affiliations

    • Clinic for Anesthesiology and Critical Care Medicine, Evangelical Diakony Hospital, Wirthstr. 11, D-79110 Freiburg, Germany
    • ,
  • Klaus F. Waschke

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Faculty for Clinical Medicine of the Heidelberg University, Mannheim, Germany

Received 24 August 2004 ,Revised 24 January 2005 ,Accepted 11 February 2005.

References 

  1. Ferner RE. Chemical disasters. Pharmacol Ther. 1993;58:157–171
  2. Daunderer M. Klinische Toxikologie der Gegengifte. Landsberg/Lech: Ecomed Verlagsgesellschaft mbH; 1987.
  3. Jasanoff S. The Bhopal disaster and the right to know. Soc Sci Med. 1988;27:1113–1123
  4. Mehta PS, Mehta AS, Mehta SJ, et al. Bhopal Tragedy's health effects. A review of methyl isocyanate toxicity. JAMA. 1990;264:2781–2787
  5. Smith AB, Zenz C. Methylisocyanate. In:  Zenz C editors. Occupational medicine principles and practical applications. Chicago: Year Book Medical Publishers Inc.; 1988;p. 745–746
  6. Kimmerle G, Eben A. Toxicity of methyl isocyanate and how to determine its quantity in air. Arch Toxicol. 1964;20:235–241
  7. Lemiere C, Romeo P, Chaboillez S, et al. Airway inflammation and functional changes after exposure to different concentrations of isocyanates. J Allergy Clin Immunol. 2002;110:641–646
  8. Sharma PN, Gaur KJBS. Radiological spectrum of lung changes in gas exposed victims. Indian J Med Res. 1987;86(Suppl.):39–44
  9. Kamat SR, Patel MH, Kohlhatkar VP, et al. Sequential respiratory changes in those exposed to the gas leak at Bhopal. Indian J Med Res. 1987;86(Suppl.):20–38
  10. Ferguson JS, Alarie Y. Long-term pulmonary impairment following a single exposure to methyl isocyanate. Toxicol Appl Pharmacol. 1991;107:253–268
  11. Engelhardt G. Effect of corticosteroids on the toxic pulmonary oedema induced by nitrogen dioxide inhalation in the rat. Arzneimittelforschung. 1987;37(5):519–523
  12. Tomaszewski CA, Thom SR. Use of hyperbaric oxygen in toxicology. Emerg Med Clin North Am. 1994;12(2):437–459
  13. Vick JA, Froehlich H. Treatment of cyanide poisoning. Mil Med. 1991;156(7):330–339
  14. Daunderer M, Theml H, Weger N. Behandlung der Blausäurevergiftung mit 4-dimethylaminophenol (4-DMAP). Med Klin. 1974;69:1626–1631
  15. Bhattacharya R. Therapeutic efficacy of sodium nitrite and 4-dimethylaminophenol or hydroxylamine co-administration against cyanide poisoning in rats. Hum Exp Toxicol. 1995;14(1):29–33
  16. Rehmann HU. Methaemoglobinemia. West J Med. 2001;175:193–196
  17. van Heijst AN, Douze JM, van Kesteren RG, van Bergen JE, van Dijk A. Therapeutic problems in cyanide poisoning. J Toxicol Clin Toxicol. 1987;25(5):383–398
  18. Nagel RL, Bookchin RM. Human haemoglobin mutants with abnormal oxygen binding. Semin Hematol. 1974;11:385–403
  19. Gall JC, Brewer GJ, Derrn RJ. Studies of glucose 6-phosphate dehydrogenase activity of individual erythrocytes: the methaemoglobin elution test for the detection of females heterozygous for G6PDH deficiency. Am J Hum Genet. 1965;17:359–362
  20. Corcoran CM, Calabro V, Tamagnini G, et al. Molecular heterogeneity underlying the G6PD Mediterranean phenotype. Hum Genet. 1992;88:688–690
  21. Dodds C, McKnight C. Cyanide toxicity after immersion and the hazards of dicobalt edetate. Br Med J (Clin Res Ed). 1985;291(6498):785–786
  22. Brouard A, Blaisot B, Bismuth C. Hydroxycobalamine in cyanide poisoning. J Toxicol Clin Exp. 1987;7(3):155–168
  23. Ohashi K, Yukioka H, Hayashi M, et al. Elevated methaemoglobin in patients with sepsis. Acta Anesthesiol Scand. 1998;42:713–716
  24. DeTorres JP, Strom JA, Jaber BL, et al. Haemodialysis-associated methaemoglobinemia in acute renal failure. Am J Kidney Dis. 2002;39:1307–1309
  25. Hall AH, Kulig KW, Rumack BH. Drug- and chemical-induced methemoglobinemia. Clinical features and management. Med Toxicol. 1986;1(4):253–260
  26. Dean BS, Lopez G, Krenzelok EP. Environmentally induced methemoglobinemia in an infant. J Toxicol Clin Toxicol. 1992;30:127–133
  27. Ellis M, Hiss Y, Shenkman L. Fatal methemoglobinemia caused by inadvertent contamination of a laxative solution with sodium nitrite. Isr J Med Sci. 1992;28:289–291
  28. Jeevaratnam K, Sriramachari S. Acute histopathological changes induced by methyl isocyanate in lungs, liver, kidneys and spleen of rats. Indian J Med Res. 1994;99:231–235
  29. Jeevarathinam K, Selvamurthy W, Ray US, et al. Acute toxicity of methyl isocyanate, administered subcutaneously in rabbits: changes in physiological, clinico-chemical and histological parameters. Toxicology. 1988;51:223–240
  30. Jeevaratnam K, Vidya S, Vaidyanathan CS. In vitro and in vivo effect of methyl isocyanate on rat liver mitochondrial respiration. Toxicol Appl Pharmacol. 1992;117:172–179
  31. Hong HL, Bucher JR, Canipe J, et al. Myelotoxicity induced in female B6C3F1 mice by inhalation of methyl isocyanate. Environ Health Perspect. 1987;72:143–148
  32. Garnacho-Montero J, Madrazo-Osuna J, Garcia-Garmendia JL, et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med. 2001;27:1288–1296
  33. Wilmer A, Nevens F, Evenepoel P, Hermans G, Fevery J. The molecular adsorbent recirculating system in patients with severe liver failure: clinical results at the K.U.. Leuven Liver. 2002;22(Suppl. 2):52–55
  34. Sills MR, Zinkham WH. Methylene blue-induced Heinz body haemolytic anaemia. Arch Pediatr Adolesc Med. 1994;148:306–310
  35. Kiese M, Lorcher W, Weger N, Zierer A. Comparative studies on the effects of toluidine blue and methylene blue on the reduction of ferrihaemoglobin in man and dog. Eur J Clin Pharmacol. 1972;4(2):115–118

☆ A Spanish translated version of the Abstract and Keywords of this article appears as Appendix at 10.1016/j.resuscitation.2005.02.008.

PII: S0300-9572(05)00148-6

doi: 10.1016/j.resuscitation.2005.02.008

Resuscitation
Volume 66, Issue 2 , Pages 231-235 , August 2005

Article Tools

* Image Usage & Resolution