Resuscitation
Volume 52, Issue 2 , Pages 203-213 , February 2002

Synaptosomal susceptibility on global ischaemia caused by cardiac arrest correlated with early and late times after recirculation in rats

  • Grzegorz Sulkowski

      Affiliations

    • Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland
  • ,
  • Jolanta Waśkiewicz

      Affiliations

    • Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland
  • ,
  • Michał Walski

      Affiliations

    • Laboratory of Ultrastructure of the Cell, Medical Research Centre Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland
  • ,
  • Sławomir Januszewski

      Affiliations

    • Laboratory of Experimental Nuclear Medicine, Medical Research Centre Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland
  • ,
  • Urszula Rafałowska

      Affiliations

    • Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland
    • Corresponding Author InformationCorresponding author. Fax: +48-22-668-5423

Received 3 November 2000 ,Revised 6 November 2000 ,Accepted 16 August 2001.

References 

  1. Siejo BK. Brain energy metabolism. Chichester, NY, Brisbane, Toronto: Wiley; 1978;
  2. Fahn S, Daris JM, Rowland LP. In: Cerebral hypoxia and its consequences. Advances in neurology. Raven Press; 1979;p. 26
  3. Safar P. Cerebral resuscitation after cardiac arrest: a review. Circulation. 1986;74:138–153
  4. Rafałowska U, Sulkowski G, Waśkiewicz J, Januszewski S, Kapuściński A. Alteration of dopamine transport and dopamine D2 receptor binding in the brain induced by early and late consequences of global ischaemia caused by cardiac arrest in the rat. Resuscitation. 2000;47:195–201
  5. Korpachev WG, Lysenkov SP, Tel LZ. Modeling clinical death and postresuscitation disease in rats. Patolog Fizjol Eksp Ter. 1982;3:78–80 in Russian
  6. Sulkowski G, Walski M, Januszewski S, Rafałowska U. Alterations in oxygen consumption and in morphology of synaptosomes induced by early and late consequences of global ischaemia caused by cardiac arrest in the rat. As abstract of Forum of European Neuroscience 2000, 24–28 June 2000. Brighton (UK). Eur J Neurosci 2000;12:121.
  7. Kawai K, Nitecka L, Ruetzler CA, Nagashima G, Joo F, Mies G, et al.  Global cerebral ischaemia associated with cardiac arrest in the rat. I: dynamics of early neuronal changes. J Cereb Blood Flow Metab. 1992;12:238–249
  8. Pluta R, Lossinsky AS, Mossakowski MJ, Faso L, Wisniewski HM. Reassessment of a new model of complete cerebral ischemia in rats. Method of induction of clinical death pathophysiology and cerebrovasenlor pathology. Acta Neuropathol. 1991;83:1–11
  9. Booth RFG, Clark JB. A rapid method for the preparation of relatively pure, metabolically competent synaptosomes from rat brain. Biochem J. 1978;176:365–370
  10. Rafałowska U, Erecińska M, Wilson DF. The effect of acute hypoxia on synaptosomes from rat brain. J Neurochem. 1980;94:1160–1165
  11. Lamprecht W, Trautschold I. ATP determination with hexikinase and glucose-6-phosphate dehydrogenase. In:  Bergmeyer HU editors. Methods of enzymatic analysis. 4:NY, London: Verlag Chemie/Academic Press; 1974;p. 2101–2110
  12. Lamprecht W, Stein P, Heinz F, Weisser H. Creatine phosphate. In:  Bergmeyer HU editors. Methods of enzymatic analysis. 4:NY, London: Verlag Chemie/Academic Press; 1974;p. 1777–1781
  13. Jaworek D, Gruber W, Bergmeyer HU. Adenosine-5′-diphosphate and adenosine-5′-monophosphate. In:  Bergmeyer HU editors. Methods of enzymatic analysis. 4:NY, London: Verlag Chemie/Academic Press; 1974;p. 2127–2131
  14. Bernt E, Bergmeyer HU, Mollering H. Creatine. In:  Bergmeyer HU editors. Methods of enzymatic analysis. 4:NY, London: Verlag Chemie/Academic Press; 1974;p. 1771–1776
  15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with Folin phenol reagent. J Biol Chem. 1951;193:265–275
  16. Pastuszko A, Wilson DF, Erecińska M. Neurotransmitter metabolism in rat brain synaptosomes: effect of anoxia and pH. J Neurochem. 1982;38:1657–1667
  17. Rafałowska U, Erecińska M, Wilson DF. Energy metabolism in rat brain synaptosomes from nembutal-anesthetized and nonanasthetized animals. J Neurochem. 1980;34:1380–1386
  18. Deutsch C, Drown C, Rafałowska U, Silver IA. Synaptosomes from rat brain: morphology, compartmentation and transmembrane pH and electrical gradients. J Neurochem. 1981;36:2063–2072
  19. Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem. 1992;53:1609–1623
  20. Gulyaeva NK, Stepanichev MY, Onutriev MV, Lazarieva NA, Zarzhetsky YK, Gurritch AM, et al. Cardiac arrest induces decrease in nitric oxide synthase activity and increase of free radical generation in rat brain regions. Neurosci Lett. 1996;220:147–150
  21. Grieb P, Ryba MS, Dębicki GS, Gordon-Krajcer W, Januszewski S, Chrapusta SJ. Changes in oxidative stress in the rat brain during post–cardiac arrest reperfusion and the effect of treatment with the free radical scavenger idebenone. Resuscitation. 1998;39:107–113
  22. Walski M, Celary-Walska R, Borowicz J. Studies on the hypothalamus and secretary nuclei of rat in the remote period following clinical death. J Hirnf. 1991;32:687–698
  23. Ratan RR, Murphy TM, Baraban MJ. Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem. 1994;62:376–379
  24. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431–1568

PII: S0300-9572(01)00451-8

Resuscitation
Volume 52, Issue 2 , Pages 203-213 , February 2002